鼠伤寒沙门氏菌组氨酸操纵子第一个基因中的两个突变影响调控。
Two mutations in the first gene of the histidine operon of Salmonella typhimurium affecting control.
作者信息
Rothman-Denes L, Martin R G
出版信息
J Bacteriol. 1971 Apr;106(1):227-37. doi: 10.1128/jb.106.1.227-237.1971.
Abstract
Two strains with mutations in the first structural gene of the histidine operon of Salmonella typhimurium were characterized. (The first structural gene specifies the first enzyme of histidine biosynthesis, phosphoribosyltransferase, which is sensitive to feedback inhibition by histidine.) One mutation, hisG3934, results in a phosphoribosyltransferase which is no longer sensitive to feedback inhibition by histidine but is instead subject to inhibition by aspartic acid. The other mutation, hisG3935, allows the histidine operon to be partially repressed by several amino acids, including aspartic acid. Analysis of hisG3935 is consistent with the hypothesis that phosphoribosyltransferase is directly involved in the regulation of the histidine operon.
摘要
对鼠伤寒沙门氏菌组氨酸操纵子第一个结构基因发生突变的两个菌株进行了特性分析。（第一个结构基因编码组氨酸生物合成的第一种酶，即磷酸核糖转移酶，它对组氨酸的反馈抑制敏感。）一种突变，hisG3934，导致产生一种不再对组氨酸反馈抑制敏感、而是受天冬氨酸抑制的磷酸核糖转移酶。另一种突变，hisG3935，使组氨酸操纵子受到包括天冬氨酸在内的几种氨基酸的部分阻遏。对hisG3935的分析与磷酸核糖转移酶直接参与组氨酸操纵子调控这一假说相符。
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