鼠伤寒沙门氏菌组氨酸操纵子第一个基因中的两个突变影响调控。
Two mutations in the first gene of the histidine operon of Salmonella typhimurium affecting control.
作者信息
Rothman-Denes L, Martin R G
出版信息
J Bacteriol. 1971 Apr;106(1):227-37. doi: 10.1128/jb.106.1.227-237.1971.
Abstract
Two strains with mutations in the first structural gene of the histidine operon of Salmonella typhimurium were characterized. (The first structural gene specifies the first enzyme of histidine biosynthesis, phosphoribosyltransferase, which is sensitive to feedback inhibition by histidine.) One mutation, hisG3934, results in a phosphoribosyltransferase which is no longer sensitive to feedback inhibition by histidine but is instead subject to inhibition by aspartic acid. The other mutation, hisG3935, allows the histidine operon to be partially repressed by several amino acids, including aspartic acid. Analysis of hisG3935 is consistent with the hypothesis that phosphoribosyltransferase is directly involved in the regulation of the histidine operon.
摘要
对鼠伤寒沙门氏菌组氨酸操纵子第一个结构基因发生突变的两个菌株进行了特性分析。（第一个结构基因编码组氨酸生物合成的第一种酶，即磷酸核糖转移酶，它对组氨酸的反馈抑制敏感。）一种突变，hisG3934，导致产生一种不再对组氨酸反馈抑制敏感、而是受天冬氨酸抑制的磷酸核糖转移酶。另一种突变，hisG3935，使组氨酸操纵子受到包括天冬氨酸在内的几种氨基酸的部分阻遏。对hisG3935的分析与磷酸核糖转移酶直接参与组氨酸操纵子调控这一假说相符。
相似文献
1
Two mutations in the first gene of the histidine operon of Salmonella typhimurium affecting control.
J Bacteriol. 1971 Apr;106(1):227-37. doi: 10.1128/jb.106.1.227-237.1971.
2
Histidine regulation in Salmonella typhimurium. XV. Procedure for the selection of mutants unable to derepress the histidine operon.
J Bacteriol. 1974 Jan;117(1):116-25. doi: 10.1128/jb.117.1.116-125.1974.
3
Histidine regulation in Salmonella typhimurium. 8. Mutations of the hisT gene.
J Bacteriol. 1971 Oct;108(1):410-4. doi: 10.1128/jb.108.1.410-414.1971.
4
Repression of the histidine operon: effect of the first enzyme on the kinetics of repression.
J Bacteriol. 1969 Mar;97(3):1283-90. doi: 10.1128/jb.97.3.1283-1290.1969.
5
Histidine regulation in Salmonella typhimurium. X. Kinetic studies of mutant histidyl transfer ribonucleic acid synthetases.
J Biol Chem. 1972 Apr 25;247(8):2302-7.
6
The pi-histidine factor of Salmonella typhimurium: a demonstration that pi-histidine factor integrates into the chromosome.
J Bacteriol. 1972 Mar;109(3):993-1000. doi: 10.1128/jb.109.3.993-1000.1972.
7
trans-Recessive mutation in the first structural gene of the histidine operon that results in constitutive expression of the operon.
J Bacteriol. 1975 Dec;124(3):1227-35. doi: 10.1128/jb.124.3.1227-1235.1975.
8
Histidyl-transfer ribonucleic acid synthetase in positive control of the histidine operon in Salmonella typhimurium.
J Bacteriol. 1974 Feb;117(2):708-16. doi: 10.1128/jb.117.2.708-716.1974.
9
A cis-trans test of the effect of the first enzyme for histidine biosynthesis on regulation of the histidine operon.
J Bacteriol. 1973 Apr;114(1):351-6. doi: 10.1128/jb.114.1.351-356.1973.
10
First enzyme of histidine biosynthesis and repression control of histidyl-transfer ribonucleic acid synthetase of Salmonella typhimurium.
J Bacteriol. 1974 Oct;120(1):390-3. doi: 10.1128/jb.120.1.390-393.1974.
引用本文的文献
1
Precursor pools and endogenous control of enzyme synthesis and activity in biosynthetic pathways.
Bacteriol Rev. 1974 Mar;38(1):1-28. doi: 10.1128/br.38.1.1-28.1974.
2
Linkage map of Salmonella typhimurium, edition IV.
Bacteriol Rev. 1972 Dec;36(4):558-86. doi: 10.1128/br.36.4.558-586.1972.
3
Multivalent repression of aspartic semialdehyde dehydrogenase in Escherichia coli K-12.
J Bacteriol. 1972 Oct;112(1):84-92. doi: 10.1128/jb.112.1.84-92.1972.
4
tyrR, a regulatory gene of tyrosine biosynthesis in Salmonella typhimurium.
J Bacteriol. 1973 Sep;115(3):1094-102. doi: 10.1128/jb.115.3.1094-1102.1973.
5
Derepression and repression of the histidine operon: role of the feedback site of the first enzyme.
J Bacteriol. 1975 Dec;124(3):1366-73. doi: 10.1128/jb.124.3.1366-1373.1975.
6
trans-Recessive mutation in the first structural gene of the histidine operon that results in constitutive expression of the operon.
J Bacteriol. 1975 Dec;124(3):1227-35. doi: 10.1128/jb.124.3.1227-1235.1975.
7
Specific binding of the first enzyme for histidine biosynthesis to the DNA of histidine operon.
Nucleic Acids Res. 1975 Nov;2(11):2021-36. doi: 10.1093/nar/2.11.2021.
8
Histidine production by a regulatory mutant of Streptomyces coelicolor.
Appl Environ Microbiol. 1977 Dec;34(6):621-5. doi: 10.1128/aem.34.6.621-625.1977.
9
Histidine mutants requiring adenine: selection of mutants with reduced hisG expression in Salmonella typhimurium.
Genetics. 1979 May;92(1):1-15. doi: 10.1093/genetics/92.1.1.
10
Biochemical-genetic study of the first enzyme of histidine biosynthesis in Salmonella typhimurium: substrate and feedback binding regions.
J Bacteriol. 1978 Jan;133(1):114-21. doi: 10.1128/jb.133.1.114-121.1978.
本文引用的文献
1
Protein measurement with the Folin phenol reagent.
J Biol Chem. 1951 Nov;193(1):265-75.
2
GENES AND PROTEINS INVOLVED IN HISTIDINE BIOSYNTHESIS IN SALMONELLA.
Brookhaven Symp Biol. 1964 Dec;17:15-52.
3
MUTANTS OF SALMONELLA TYPHIMURIUM RESISTANT TO FEEDBACK INHIBITION BY L-HISTIDINE.
Genetics. 1964 Oct;50(4):611-23. doi: 10.1093/genetics/50.4.611.
4
EFFECT OF ALPHA-METHYLHISTIDINE ON THE CONTROL OF HISTIDINE SYNTHESIS.
J Mol Biol. 1964 Sep;9:670-82. doi: 10.1016/s0022-2836(64)80174-1.
5
INTERMEDIATES IN THE EARLY STEPS OF HISTIDINE BIOSYNTHESIS.
J Biol Chem. 1964 Jun;239:1848-55.
6
A NEW DEVICE FOR CONTROLLING THE GROWTH RATE OF MICROORGANISMS: THE EXPONENTIAL GRADIENT GENERATOR.
Anal Biochem. 1964 May;8:43-53. doi: 10.1016/0003-2697(64)90167-8.
7
CO-LINEARITY OF THE GENE WITH THE POLYPEPTIDE CHAIN.
Nature. 1964 Jan 4;201:13-7. doi: 10.1038/201013a0.
8
Interference with the feed-back control of histidine biosynthesis.
J Biol Chem. 1961 Aug;236:2261-7.
9
The first step of histidine biosynthesis.
J Biol Chem. 1961 Jul;236:2019-26.
10
Acetylornithinase of Escherichia coli: partial purification and some properties.
J Biol Chem. 1956 Jan;218(1):97-106.
Zotero 插件