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Host specificity of DNA produced by Escherichia coli. XI. In vitro modification of phage fd replicative form.大肠杆菌产生的DNA的宿主特异性。十一。噬菌体fd复制型的体外修饰
Proc Natl Acad Sci U S A. 1969 Jun;63(2):556-62. doi: 10.1073/pnas.63.2.556.
2
Host specificity of DNA produced by Escherichia coli, X. In vitro restriction of phage fd replicative form.大肠杆菌产生的DNA的宿主特异性，X. 噬菌体fd复制型的体外限制
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[In vitro modification of the replicative form of fd bacteriophage].
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J Biochem. 1970 Mar;67(3):497-9. doi: 10.1093/oxfordjournals.jbchem.a129272.

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Host specificity of DNA produced by Escherichia coli. 9. Host-controlled modification of bacteriophage fd.大肠杆菌产生的DNA的宿主特异性。9. 噬菌体fd的宿主控制修饰。
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Host specificity of DNA produced by Escherichia coli: bacterial mutations affecting the restriction and modification of DNA.大肠杆菌产生的DNA的宿主特异性：影响DNA限制与修饰的细菌突变
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Endonuclease-I-deficient and ribonuclease I-deficient Escherichia coli mutants.核酸内切酶I缺陷型和核糖核酸酶I缺陷型大肠杆菌突变体。
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Formation of merodiploids in matings with a class of Rec- recipient strains of Escherichia coli K12.在与一类大肠杆菌K12 Rec-受体菌株交配时形成部分二倍体。
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大肠杆菌产生的DNA的宿主特异性。十一。噬菌体fd复制型的体外修饰

Host specificity of DNA produced by Escherichia coli. XI. In vitro modification of phage fd replicative form.

作者信息

Kühnlein U, Linn S, Arber W

出版信息

Proc Natl Acad Sci U S A. 1969 Jun;63(2):556-62. doi: 10.1073/pnas.63.2.556.

DOI:10.1073/pnas.63.2.556
PMID:4895540
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC223599/
Abstract

An enzymatic activity, having the properties expected of a B-specific host-controlled modification enzyme, has been purified from an extract of Escherichia coli strain B. This activity renders the unmodified replicative form of phage fd resistant to B-specific restriction and is only present in strains carrying intact genes for type B modification. In phosphate buffer, the enzyme acts optimally at pH 6 and is dependent upon a single cofactor, S-adenosylmethionine.

摘要

已从大肠杆菌B菌株提取物中纯化出一种具有B特异性宿主控制修饰酶预期特性的酶活性。这种活性使噬菌体fd的未修饰复制型对B特异性限制具有抗性，并且仅存在于携带完整B型修饰基因的菌株中。在磷酸盐缓冲液中，该酶在pH 6时作用最佳，并且依赖于单一辅因子S-腺苷甲硫氨酸。