大肠杆菌中脱氧核糖核酸二级修饰的遗传控制。
Genetic control of the secondary modification of deoxyribonucleic acid in Escherichia coli.
作者信息
Mamelak L, Boyer H W
出版信息
J Bacteriol. 1970 Oct;104(1):57-62. doi: 10.1128/jb.104.1.57-62.1970.
Abstract
The wild-type restriction and modification alleles of Escherichia coli K-12 and B were found to have no measurable effect on the patterns of methylated bases in the deoxyribonucleic acid (DNA) of these strains. The genetic region controlling the methylation of cytosine in E. coli K-12 was mapped close to his, and the presence or absence of this gene in E. coli B or E. coli K had no effect on the restriction and modification properties of these strains. Thus, only a few of the methylated bases in the DNA of these strains are involved in host modification, and the biological role of the remainder remains obscure.
摘要
已发现大肠杆菌K-12和B的野生型限制与修饰等位基因对这些菌株的脱氧核糖核酸（DNA）中甲基化碱基的模式没有可测量的影响。控制大肠杆菌K-12中胞嘧啶甲基化的遗传区域被定位在靠近组氨酸（his）的位置，大肠杆菌B或大肠杆菌K中该基因的存在与否对这些菌株的限制和修饰特性没有影响。因此，这些菌株DNA中只有少数甲基化碱基参与宿主修饰，其余甲基化碱基的生物学作用仍不清楚。
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