Gross P A, Davis A E
J Clin Microbiol. 1979 Sep;10(3):382-4. doi: 10.1128/jcm.10.3.382-384.1979.
In influenza immunization trials, patients who were seronegative by the hemagglutination inhibition test could be divided into two groups according to preimmunization levels of neutralizing (Neut) and neuraminidase inhibition (NI) antibodies. The group with low levels of Neut and NI antibodies usually developed adequate levels of hemagglutination inhibition antibody after one dose of vaccine, and the group with undetectable Neut and NI antibodies did not.
在流感免疫试验中,通过血凝抑制试验检测为血清阴性的患者,可根据免疫前中和(Neut)抗体和神经氨酸酶抑制(NI)抗体水平分为两组。Neut和NI抗体水平较低的组在接种一剂疫苗后通常会产生足够水平的血凝抑制抗体,而Neut和NI抗体检测不到的组则不会。