鼠伤寒沙门氏菌突变体中甲硫氨酸反馈敏感酶的调控
Regulation of the methionine feedback-sensitive enzyme in mutants of Salmonella typhimurium.
作者信息
Lawrence D A
出版信息
J Bacteriol. 1972 Jan;109(1):8-11. doi: 10.1128/jb.109.1.8-11.1972.
Abstract
Assay of the first enzyme unique to methionine biosynthesis, homoserine-O-transsuccinylase, in metJ and metK regulatory mutants of Salmonella typhimurium showed that synthesis of the enzyme was derepressed seven- and fourfold, respectively. The possibility of noncoordinate regulation of the methionine enzymes is discussed. In metA feedback-resistant mutants, the enzyme activity can be inhibited in vitro by 10 mmS-adenosylmethionine but not by 10 mm l-methionine; hence, the synergistic inhibition found for the wild-type enzyme is not effective in these latter mutants.
摘要
对鼠伤寒沙门氏菌metJ和metK调控突变体中蛋氨酸生物合成特有的第一种酶——高丝氨酸-O-转琥珀酰酶的测定表明，该酶的合成分别被解除阻遏7倍和4倍。讨论了蛋氨酸酶非协同调节的可能性。在metA反馈抗性突变体中，该酶活性在体外可被10 mM S-腺苷甲硫氨酸抑制，但不能被10 mM L-蛋氨酸抑制；因此，野生型酶的协同抑制在这些突变体中无效。
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