Avezaat C J, van Eijndhoven J H, Wyper D J
J Neurol Neurosurg Psychiatry. 1979 Aug;42(8):687-700. doi: 10.1136/jnnp.42.8.687.
In six anaesthetised and ventilated dogs the CSF pulse pressure was compared with the volume-pressure response (VPR) during continuous inflation of an extradural balloon. Both pulse pressure and VPR increased linearly with the ventricular fluid pressure (VFP) up to a mean VFP of 60 mmHg. At this pressure a breakpoint occurred above which the CSF pulse pressure showed a steeper linear increase, while the VPR remained constant. It is suggested that the breakpoint is related to failure of autoregulation, and that in non-autoregulating patients the CSF pulse pressure is a better parameter of the clinical state than the VPR.
在六只麻醉并进行机械通气的狗身上,在硬膜外球囊持续充气过程中,对脑脊液脉压与容量-压力反应(VPR)进行了比较。脉压和VPR均随脑室液压力(VFP)线性增加,直至平均VFP达到60 mmHg。在此压力时出现一个转折点,高于此点,脑脊液脉压呈更陡的线性增加,而VPR保持恒定。提示该转折点与自动调节功能衰竭有关,并且在无自动调节功能的患者中,脑脊液脉压比VPR是更好的临床状态参数。