交叉听觉反应联合视觉和体感诱发电位在多发性硬化症诊断中的应用
Crossed acoustic response combined with visual and somatosensory evoked responses in the diagnosis of multiple sclerosis.
作者信息
Clifford-Jones R E, Clarke G P, Mayles P
出版信息
J Neurol Neurosurg Psychiatry. 1979 Aug;42(8):749-52. doi: 10.1136/jnnp.42.8.749.
The crossed acoustic response, (CAR), a recently introduced test of brainstem function, has been studied in 66 patients with multiple sclerosis and 53 control subjects, and compared with conventional visual and somatosensory evoked responses (VER, SER). A latency abnormality was found in the CAR in 73% of patients, in the VER in 63%, and in the SER in 37%. Abnormalities have been related to the presence or absence of clinically detectable signs. All three responses detected subclinical lesions by showing abnormality in a proportion of multiple sclerosis patients who had no corresponding abnormal clinical signs (CAR 69%, VER 42%, SER 29%). The best diagnostic combination of responses was VER and CAR. Ninety per cent of patients had at least one of these two responses abnormal.
交叉听觉反应（CAR）是最近引入的一种脑干功能测试，已在66例多发性硬化症患者和53名对照受试者中进行了研究，并与传统的视觉和体感诱发电位（VER、SER）进行了比较。73%的患者CAR潜伏期异常，63%的患者VER潜伏期异常，37%的患者SER潜伏期异常。异常情况与临床可检测体征的有无有关。所有这三种反应均通过在一部分没有相应异常临床体征的多发性硬化症患者中显示异常，检测出了亚临床病变（CAR为69%，VER为42%，SER为29%）。最佳的反应诊断组合是VER和CAR。90%的患者这两种反应中至少有一种异常。
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