Sedgwick E M, Illis L S, Tallis R C, Thornton A R, Abraham P, El-Negamy E, Docherty T B, Soar J S, Spencer S C, Taylor F M
J Neurol Neurosurg Psychiatry. 1980 Jan;43(1):15-24. doi: 10.1136/jnnp.43.1.15.
Cervical somatosensory evoked potentials, brainstem evoked potentials, visual evoked potentials, and the cerebral contingent negative variation were recorded in patients with definite multiple sclerosis before, during, and after spinal cord stimulation. Improvements were seen in the cervical somatosensory and brainstem evoked potentials but neither the visual evoked potential nor the contingent negative variation changed in association with spinal cord stimulation. The results indicate that spinal cord stimulation acts at spinal and brainstem levels and that the clinical improvements seen in patients are caused by an action at these levels rather than by any cerebral arousal or motivational effect. The evoked potentials were not useful in predicting which patients were likely to respond to stimulation.
在脊髓刺激前、刺激期间和刺激后，对明确诊断为多发性硬化症的患者记录了颈体感诱发电位、脑干诱发电位、视觉诱发电位和大脑关联性负变。颈体感诱发电位和脑干诱发电位有改善，但视觉诱发电位和关联性负变均未随脊髓刺激而改变。结果表明，脊髓刺激作用于脊髓和脑干水平，患者出现的临床改善是由这些水平的作用引起的，而非任何大脑觉醒或动机效应。诱发电位对于预测哪些患者可能对刺激有反应并无帮助。
