氨基糖苷类抗生素：在携带R因子的大肠杆菌中通过磷酸化作用而失活
Aminoglycoside antibiotics: inactivation by phosphorylation in Escherichia coli carrying R factors.
作者信息
Ozanne B, Benveniste R, Tipper D, Davies J
出版信息
J Bacteriol. 1969 Nov;100(2):1144-6. doi: 10.1128/jb.100.2.1144-1146.1969.
Abstract
R-factor strains which are streptomycin-resistant and spectinomycin-sensitive have been found to inactivate streptomycin by a new mechanism. The 3'-OH group of the 2-deoxy-2-methylamino-l-glucopyranosyl moiety is phosphorylated.
摘要
已发现对链霉素耐药且对壮观霉素敏感的R因子菌株通过一种新机制使链霉素失活。2-脱氧-2-甲氨基-L-吡喃葡萄糖基部分的3'-OH基团被磷酸化。
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本文引用的文献
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Resistance factor-mediated streptomycin resistance.耐药因子介导的链霉素耐药性。
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Phosphorylation and inactivation of aminoglycosidic antibiotics by E. coli carrying R factor.携带R因子的大肠杆菌对氨基糖苷类抗生素的磷酸化及失活作用
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Isolation and structure of kanamycin inactivated by a cell free system of kanamycin-resistant E. coli.由卡那霉素抗性大肠杆菌无细胞系统使卡那霉素失活后的分离及结构研究
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Studies on adenylylstreptomycin, a product of streptomycin inactivation by E. coli carrying the R-factor.关于腺苷链霉素的研究，腺苷链霉素是携带R因子的大肠杆菌使链霉素失活的产物。
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Isolation of kanamycin and paromamine inactivated by E. coli carrying R factor.
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Enzymatic inactivation of streptomycin by R factor-resistant Escherichia coli.R因子抗性大肠杆菌对链霉素的酶促失活作用
Nature. 1968 Jul 20;219(5151):288-91. doi: 10.1038/219288a0.
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The release of enzymes by osmotic shock from Escherichia coli in exponential phase.处于对数期的大肠杆菌通过渗透休克释放酶。
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Adenylylstreptomycin, a product of streptomycin inactivated by E. coli carrying R factor.腺苷链霉素，一种由携带R因子的大肠杆菌使链霉素失活后产生的产物。
J Antibiot (Tokyo). 1968 Jan;21(1):81-2. doi: 10.7164/antibiotics.21.81.
10
Phosphorylative inactivation of aminoglycosidic antibiotics by Escherichia coli carrying R factor.携带R因子的大肠杆菌对氨基糖苷类抗生素的磷酸化失活作用
Science. 1967 Sep 29;157(3796):1559-61.
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