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Inactivation of dihydrostreptomycin and spectinomycin by Staphylococcus aureus.金黄色葡萄球菌对双氢链霉素和壮观霉素的灭活作用
Antimicrob Agents Chemother. 1974 Jun;5(6):553-7. doi: 10.1128/AAC.5.6.553.
2
Effect of enzymatic adenylylation on dihydrostreptomycin accumulation in Escherichia coli carrying an R-factor: model explaining aminoglycoside resistance by inactivating mechanisms.酶促腺苷酸化对携带R因子的大肠杆菌中二氢链霉素积累的影响：通过失活机制解释氨基糖苷类耐药性的模型。
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Streptomycin and Spectinomycin resistance mediated by plasmids.由质粒介导的链霉素和壮观霉素耐药性。
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Derivatives of 4-dihydro-4-deoxy-4(R)-amino spectinomycin and their activity against susceptible and resistant Escherichia coli strains.4-二氢-4-脱氧-4(R)-氨基壮观霉素的衍生物及其对敏感和耐药大肠杆菌菌株的活性。
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4
Gentic properties of an R factor carrying resistance to aminolgycoside antibiotics.携带对氨基糖苷类抗生素耐药性的R因子的遗传特性。
J Bacteriol. 1975 Jul;123(1):329-35. doi: 10.1128/jb.123.1.329-335.1975.
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R factor-mediated aminoglycoside antibiotic resistance in Pseudomonas aeruginosa: a new aminoglycoside 6'-N-acetyltransferase.R因子介导的铜绿假单胞菌对氨基糖苷类抗生素的耐药性：一种新的氨基糖苷6'-N-乙酰基转移酶
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Resistance factor-mediated spectinomycin resistance.耐药因子介导的大观霉素耐药性。
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Enzymatic Adenylylation of Streptomycin and Spectinomycin by R-Factor-Resistant Escherichia coli.R 因子抗性大肠杆菌对链霉素和壮观霉素的酶腺苷酰化作用。
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Agar layer method for production of high titer phage stocks.用于生产高滴度噬菌体原液的琼脂层法。
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Inactivation of kanamycin, neomycin, and streptomycin by enzymes obtained in cells of Pseudomonas aeruginoa.铜绿假单胞菌细胞中获得的酶对卡那霉素、新霉素和链霉素的灭活作用。
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Aminoglycoside antibiotics: inactivation by phosphorylation in Escherichia coli carrying R factors.氨基糖苷类抗生素：在携带R因子的大肠杆菌中通过磷酸化作用而失活
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Resistance factor-mediated streptomycin resistance.耐药因子介导的链霉素耐药性。
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Studies on adenylylstreptomycin, a product of streptomycin inactivation by E. coli carrying the R-factor.关于腺苷链霉素的研究，腺苷链霉素是携带R因子的大肠杆菌使链霉素失活的产物。
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Enzymatic inactivation of streptomycin by R factor-resistant Escherichia coli.R因子抗性大肠杆菌对链霉素的酶促失活作用
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Isolation of the rec mutants in Staphylococcus aureus.金黄色葡萄球菌中rec突变体的分离
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Adenylylstreptomycin, a product of streptomycin inactivated by E. coli carrying R factor.腺苷链霉素，一种由携带R因子的大肠杆菌使链霉素失活后产生的产物。
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金黄色葡萄球菌对双氢链霉素和壮观霉素的灭活作用

Inactivation of dihydrostreptomycin and spectinomycin by Staphylococcus aureus.

作者信息

Kawabe H, Inoue M, Mitsuhashi S

出版信息

Antimicrob Agents Chemother. 1974 Jun;5(6):553-7. doi: 10.1128/AAC.5.6.553.

DOI:10.1128/AAC.5.6.553
PMID:15825403
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC429012/
Abstract

Three types of Staphylococcus aureus strains were isolated with respect to streptomycin (SM) and spectinomycin (SPC) resistance, namely, SM(r)SPC(r), SM(r)SPC(s), and SM(s)SPC(r) (r, resistant; s, sensitive). Curing experiments and transduction analysis of strain MS7990 (SM(r).SPC(r).EM(r)) (EM, erythromycin) disclosed that the loci governing SM and SPC resistance are different and exist on different nontransferable plasmids (r factor), one plasmid carrying the genes governing SM resistance and another possessing the genes governing resistance to both SPC and EM. Strain MS7990 (SM(r).SPC(r)) inactivated both drugs by adenylylation. Similarly, the SM(r)SPC(s) and SM(s)SPC(r) strains inactivated SM and SPC, respectively, by adenylylation, although the adenylylated positions of both drugs have not been established as yet. The adenylylated SM in staphylococci was shown to be different from 3''-adenylyl-SM, indicating the possibility of the existence of a different enzyme from SM3''-adenylyl transferase demonstrated in Escherichia coli strains.

摘要

根据对链霉素（SM）和壮观霉素（SPC）的耐药性，分离出三种金黄色葡萄球菌菌株，即SM(r)SPC(r)、SM(r)SPC(s)和SM(s)SPC(r)（r表示耐药，s表示敏感）。对菌株MS7990（SM(r).SPC(r).EM(r)）（EM为红霉素）进行的消除实验和转导分析表明，控制SM和SPC耐药性的基因座不同，且存在于不同的非转移性质粒（r因子）上，一个质粒携带控制SM耐药性的基因，另一个质粒则拥有控制对SPC和EM耐药性的基因。菌株MS7990（SM(r).SPC(r)）通过腺苷酸化使两种药物失活。同样，SM(r)SPC(s)和SM(s)SPC(r)菌株分别通过腺苷酸化使SM和SPC失活，尽管两种药物的腺苷酸化位置尚未确定。葡萄球菌中腺苷酸化的SM与3''-腺苷酰-SM不同，这表明可能存在一种与在大肠杆菌菌株中发现的SM3''-腺苷酰转移酶不同的酶。