Cox J C, Hamilton R C, Attwood H D
J Protozool. 1979 May;26(2):260-5. doi: 10.1111/j.1550-7408.1979.tb02776.x.
Rabbits infected either orally or intratracheally with cell culture-grown Encephalitozoon cuniculi were monitored regularly for serum antibody levels and E. cuniculi in the urine. Their responses were compared with intravenously inoculated and uninoculated control rabbits. All rabbits receiving E. cuniculi developed serum antibodies, generally within 3 weeks, and excreted E. cuniculi by 6 weeks. In the acute stage of infection, the organs most affected were lung, kidney and liver; the brain and gut were unaffected. However, during chronic infection, the brain, kidney, and heart were the only organs found to be involved. Antibody levels were very high at this stage. Thus both the oral and tracheal routes may be normal routes of infection with E. cuniculi in adult rabbits.
通过口服或气管内接种细胞培养生长的兔脑炎微孢子虫的兔子，定期监测其血清抗体水平和尿液中的兔脑炎微孢子虫。将它们的反应与静脉接种和未接种的对照兔子进行比较。所有感染兔脑炎微孢子虫的兔子通常在3周内产生血清抗体，并在6周时排出兔脑炎微孢子虫。在感染急性期，受影响最严重的器官是肺、肾和肝；脑和肠道未受影响。然而，在慢性感染期间，发现仅脑、肾和心脏受累。此时抗体水平非常高。因此，口服和气管内途径可能是成年兔子感染兔脑炎微孢子虫的正常途径。
