腺苷和脱氧腺苷对大肠杆菌K-12中胸苷掺入及分解代谢的影响。
Effect of adenosine and deoxyadenosine on the incorporation and breakdown of thymidine in Escherichia coli K-12.
作者信息
Yagil E, Rosner A
出版信息
J Bacteriol. 1970 Aug;103(2):417-21. doi: 10.1128/jb.103.2.417-421.1970.
Abstract
Deoxyadenosine (AdR) and adenosine (AR) enhance the incorporation of thymidine (TdR) into bacterial deoxyribonucleic acid (DNA) by the inhibition of TdR phosphorolysis in vivo. Neither of the purine nucleosides has an effect on the reaction catalyzed by TdR phosphorylase in vitro. AdR induces TdR phosphorylase and both purine nucleosides induce purine nucleoside phosphorylase. AR can stimulate uptake of more TdR into bacterial DNA than AdR.
摘要
脱氧腺苷（AdR）和腺苷（AR）通过在体内抑制胸苷（TdR）磷酸解作用，增强了TdR掺入细菌脱氧核糖核酸（DNA）的过程。这两种嘌呤核苷在体外对TdR磷酸化酶催化的反应均无影响。AdR诱导TdR磷酸化酶，而这两种嘌呤核苷均诱导嘌呤核苷磷酸化酶。与AdR相比，AR能刺激更多TdR摄取到细菌DNA中。
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