5-氟-2'-脱氧尿苷在大肠杆菌中的磷酸解作用及其被核苷的抑制作用
Phosphorolysis of 5-fluoro-2'-deoxyuridine in Escherichia coli and its inhibition by nucleosides.
作者信息
Yagil E, Rosner A
出版信息
J Bacteriol. 1971 Nov;108(2):760-4. doi: 10.1128/jb.108.2.760-764.1971.
Abstract
The effect of ribonucleosides and deoxyribonucleosides on the phosphorolysis of 5-fluoro-2'-deoxyuridine (FUdR) was examined in cells of Escherichia coli. All nucleosides tested except guanosine and deoxyguanosine inhibited phosphorolysis. By using genetically marked strains it was found that in vivo FUdR is a specific substrate of thymidine phosphorylase.
摘要
在大肠杆菌细胞中检测了核糖核苷和脱氧核糖核苷对5-氟-2'-脱氧尿苷（FUdR）磷酸解的影响。除鸟苷和脱氧鸟苷外，所有测试的核苷均抑制磷酸解。通过使用基因标记菌株发现，体内FUdR是胸苷磷酸化酶的特异性底物。
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本文引用的文献
1
FLUORINATED PYRIMIDINES. 23. FURTHER STUDIES ON NUCLEOSIDE PHOSPHORYLASE.
Biochim Biophys Acta. 1964 Dec 16;91:639-41. doi: 10.1016/0926-6550(64)90013-1.
2
SUBSTRATE SPECIFICITY AND INDUCTION OF THYMIDINE PHOSPHORYLASE IN ESCHERICHIA COLI.大肠杆菌中胸苷磷酸化酶的底物特异性与诱导作用
J Biol Chem. 1964 Jun;239:1789-93.
3
SPECIFICITY OF MOUSE URIDINE PHOSPHORYLASE. CHROMATOGRAPHY, PURIFICATION, AND PROPERTIES.小鼠尿苷磷酸化酶的特异性。色谱分析、纯化及性质
J Biol Chem. 1964 Mar;239:805-12.
4
5
STUDIES OF FLUORINATED PYRIMIDINES. XVIII. THE DEGRADATION OF 5-FLUORO-2'-DEOXYURIDINE AND RELATED COMPOUNDS BY NUCLEOSIDE PHOSPHORYLASE.氟化嘧啶的研究。十八。核苷磷酸化酶对5-氟-2'-脱氧尿苷及相关化合物的降解
Biochemistry. 1963 May-Jun;2:566-72. doi: 10.1021/bi00903a031.
6
Studies on fluorinated pyrimidines. XIII. Inhibition of thymidylate synthetase.氟化嘧啶的研究。十三。胸苷酸合成酶的抑制作用。
J Biol Chem. 1961 Nov;236:3006-13.
7
Uridine and deoxyuridine phosphorylases from Ehrlich ascites tumor.
Biochim Biophys Acta. 1961 Jul 22;51:138-47. doi: 10.1016/0006-3002(61)91024-1.
8
Genetic control of repression of alkaline phosphatase in E. coli.大肠杆菌中碱性磷酸酶阻遏的遗传控制
J Mol Biol. 1961 Aug;3:425-38. doi: 10.1016/s0022-2836(61)80055-7.
9
10
Cancer chemotherapy with purine and pyrimidine analogues.
Annu Rev Pharmacol. 1967;7:101-24. doi: 10.1146/annurev.pa.07.040167.000533.
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