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5-氟-2'-脱氧尿苷在大肠杆菌中的磷酸解作用及其被核苷的抑制作用

Phosphorolysis of 5-fluoro-2'-deoxyuridine in Escherichia coli and its inhibition by nucleosides.

作者信息

Yagil E, Rosner A

出版信息

J Bacteriol. 1971 Nov;108(2):760-4. doi: 10.1128/jb.108.2.760-764.1971.

DOI:10.1128/jb.108.2.760-764.1971
PMID:4256858
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC247137/
Abstract

The effect of ribonucleosides and deoxyribonucleosides on the phosphorolysis of 5-fluoro-2'-deoxyuridine (FUdR) was examined in cells of Escherichia coli. All nucleosides tested except guanosine and deoxyguanosine inhibited phosphorolysis. By using genetically marked strains it was found that in vivo FUdR is a specific substrate of thymidine phosphorylase.

摘要

在大肠杆菌细胞中检测了核糖核苷和脱氧核糖核苷对5-氟-2'-脱氧尿苷（FUdR）磷酸解的影响。除鸟苷和脱氧鸟苷外，所有测试的核苷均抑制磷酸解。通过使用基因标记菌株发现，体内FUdR是胸苷磷酸化酶的特异性底物。

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Phosphorolysis of 5-fluoro-2'-deoxyuridine in Escherichia coli and its inhibition by nucleosides.5-氟-2'-脱氧尿苷在大肠杆菌中的磷酸解作用及其被核苷的抑制作用
J Bacteriol. 1971 Nov;108(2):760-4. doi: 10.1128/jb.108.2.760-764.1971.
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SUBSTRATE SPECIFICITY AND INDUCTION OF THYMIDINE PHOSPHORYLASE IN ESCHERICHIA COLI.大肠杆菌中胸苷磷酸化酶的底物特异性与诱导作用
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Genetic control of repression of alkaline phosphatase in E. coli.大肠杆菌中碱性磷酸酶阻遏的遗传控制
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