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核糖体结构与功能的浮现。

Ribosome structure and function emergent.

作者信息

Kurland C G

出版信息

Science. 1970 Sep 18;169(3951):1171-7. doi: 10.1126/science.169.3951.1171.

Abstract

Although the corresponding data for 50S subunits are still being assembled, it is doubtful that these data will significantly alter the general features of ribosome structure that have emerged from analysis of the 30S subunits. One overwhelming characteristic of the ribosome is its apparent complexity, which is reflected both in the diversity of ribosomal components and in their dissymmetric arrangement. The absence of repeat-structures implies that the functions of the ribosome are dissymmetric; this should influence the choice of models for protein synthesis.

摘要

尽管50S亚基的相应数据仍在整理之中,但这些数据是否会显著改变通过对30S亚基分析所呈现出的核糖体结构的总体特征,仍值得怀疑。核糖体的一个压倒性特征是其明显的复杂性,这在核糖体组分的多样性及其不对称排列中都有所体现。不存在重复结构意味着核糖体的功能是不对称的;这应该会影响蛋白质合成模型的选择。

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