哺乳动物释放因子介导的肽链终止
Peptide chain termination with mammalian release factor.
作者信息
Goldstein J L, Beaudet A L, Caskey C T
出版信息
Proc Natl Acad Sci U S A. 1970 Sep;67(1):99-106. doi: 10.1073/pnas.67.1.99.
Abstract
We report a method for the in vitro study of peptide chain termination in mammals. A proteinaceous release factor has been isolated from rabbit reticulocyte extracts. This factor and a polyribonucleotide template containing the bases U and A stimulate the release of N-formylmethionine from mammalian [N-formylmethionyl-tRNA(f).ribosome] intermediates. Our studies suggest that UAA is a terminator codon for mammalian cells.
摘要
我们报道了一种用于哺乳动物肽链终止体外研究的方法。已从兔网织红细胞提取物中分离出一种蛋白质释放因子。该因子和一个含有碱基U和A的多聚核糖核苷酸模板可刺激N-甲酰甲硫氨酸从哺乳动物的[N-甲酰甲硫氨酰-tRNA(f).核糖体]中间体中释放出来。我们的研究表明UAA是哺乳动物细胞的终止密码子。
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Proc Natl Acad Sci U S A. 1970 Sep;67(1):99-106. doi: 10.1073/pnas.67.1.99.
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