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结核菌素活性碳水化合物，可诱导巨噬细胞迁移抑制，但不诱导淋巴细胞转化。

Tuberculin-active carbohydrate that induces inhibition of macrophage migration but not lymphocyte transformation.

作者信息

Chaparas S D, Thor D E, Godfrey H P, Baer H, Hedrick S R

出版信息

Science. 1970 Nov 6;170(3958):637-9. doi: 10.1126/science.170.3958.637.

DOI:10.1126/science.170.3958.637
PMID:4919183
Abstract

A tuberculin carbohydrate fraction, GAE, in sensitized animals induced a delayed type of skin reactivity and inhibited the migration of macrophages but failed to stimulate lymphocyte transformation in vitro. Tuberculin protein-containing fractions were active in each test. These results show that in vitro lymphocyte transformation is not necessarily a corollary of delayed type hypersensitivity.

摘要

一种结核菌素碳水化合物组分GAE，在致敏动物中可诱导迟发型皮肤反应性，并抑制巨噬细胞迁移，但在体外不能刺激淋巴细胞转化。含结核菌素蛋白的组分在每项试验中均有活性。这些结果表明，体外淋巴细胞转化不一定是迟发型超敏反应的必然结果。

相似文献

1
Tuberculin-active carbohydrate that induces inhibition of macrophage migration but not lymphocyte transformation.结核菌素活性碳水化合物，可诱导巨噬细胞迁移抑制，但不诱导淋巴细胞转化。
Science. 1970 Nov 6;170(3958):637-9. doi: 10.1126/science.170.3958.637.
2
Comparison of lymphocyte transformation, inhibition of macrophage migration and skin tests using dialyzable and nondialyzable tuberculin fractions from Mycobacterium bovis (BCG).使用来自牛分枝杆菌（卡介苗）的可透析和不可透析结核菌素组分进行淋巴细胞转化、巨噬细胞迁移抑制及皮肤试验的比较。
J Immunol. 1971 Jul;107(1):149-53.
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Inhibition of macrophage migration by a skin-reactive polysaccharide from BCG culture filtrates.卡介苗培养滤液中一种皮肤反应性多糖对巨噬细胞迁移的抑制作用。
J Immunol. 1969 Jun;102(6):1466-73.
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Delayed skin reactivity to carbohydrate and protein fractions of Mycobacterium bovis (BCG) culture filtrate in the absence and presence of serum antibody.在有无血清抗体的情况下，对牛分枝杆菌（卡介苗）培养滤液中碳水化合物和蛋白质组分的迟发性皮肤反应。
J Immunol. 1966 Feb;96(2):353-7.
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[Attempts at isolation and characterization of immunogenically active fractions from Mycobacterium tuberculosis and Mycobacterium bovis (BCG). IV. Immunobiologic properties of the fractions].[从结核分枝杆菌和牛分枝杆菌（卡介苗）中分离和鉴定免疫活性成分的尝试。IV. 各成分的免疫生物学特性]
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Specificity of antigenic fractions of tuberculin.结核菌素抗原成分的特异性
Acta Microbiol Acad Sci Hung. 1976;23(1):23-8.
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Macrophage aggregation in vitro: a correlate of delayed hypersensitivity.巨噬细胞体外聚集：迟发型超敏反应的一个相关因素。
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Skin reaction, inhibition of macrophage migration, and lymphocyte transformation with tuberculin active peptide (TAP) and arabinogalactan obtained from tubercle bacilli.皮肤反应、巨噬细胞游走抑制以及结核菌素活性肽（TAP）和从结核杆菌中提取的阿拉伯半乳聚糖引起的淋巴细胞转化。
Int Arch Allergy Appl Immunol. 1975;49(5):585-96. doi: 10.1159/000231440.
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Reactivity of purified proteins and polysaccharides from Mycobacterium tuberculosis in delayed skin test and cultured lymphocyte mitogenesis assays.结核分枝杆菌纯化蛋白和多糖在迟发型皮肤试验及培养淋巴细胞有丝分裂原试验中的反应性
Infect Immun. 1974 Jan;9(1):44-7. doi: 10.1128/iai.9.1.44-47.1974.
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Relation between delayed skin reactivity and macrophage migration inhibition or lymphocyte transformation in tuberculin-type hypersensitivity and Jones-Mote hypersensitivity.结核菌素型超敏反应和琼斯-莫特超敏反应中迟发性皮肤反应性与巨噬细胞游走抑制或淋巴细胞转化之间的关系。
Microbiol Immunol. 1977;21(2):99-110. doi: 10.1111/j.1348-0421.1977.tb02812.x.

引用本文的文献

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The compartmentalization of antigen-reactive lymphocytes in desensitized guinea pigs.脱敏豚鼠中抗原反应性淋巴细胞的区室化
J Exp Med. 1971 Sep 1;134(3 Pt 1):741-50. doi: 10.1084/jem.134.3.741.
2
Cell-mediated immune responses to chlamydial antigens in guinea pigs injected with inactivated chlamydiae.对注射灭活衣原体的豚鼠中衣原体抗原的细胞介导免疫反应。
Med Microbiol Immunol. 1980;168(2):91-101. doi: 10.1007/BF02121757.
3
Lymphocyte-mediated cytotoxicity in vitro. Effect of enhancing antisera.体外淋巴细胞介导的细胞毒性。增强抗血清的作用。
J Exp Med. 1971 Nov 1;134(5):1238-52. doi: 10.1084/jem.134.5.1238.
4
Experimental allergic encephalitis. Dissociation of cellular immunity to brain protein and disease production.实验性变应性脑脊髓炎。对脑蛋白的细胞免疫与疾病产生的分离。
J Exp Med. 1972 Jul 1;136(1):156-74. doi: 10.1084/jem.136.1.156.
5
Cell-mediated immunity in periodontal disease; cytotoxicity, migration inhibition and lymphocyte transformation studies.牙周病中的细胞介导免疫；细胞毒性、迁移抑制及淋巴细胞转化研究
Immunology. 1972 Jan;22(1):141-5.
6
Migration inhibition of mouse macrophages by Brucella antigens.布鲁氏菌抗原对小鼠巨噬细胞迁移的抑制作用。
Infect Immun. 1971 Oct;4(4):516-8. doi: 10.1128/iai.4.4.516-518.1971.
7
[Effect of L-asparaginase of E. coli on the macrophage migration inhibition and the lymphocyte transformation by tuberculin].
Klin Wochenschr. 1971 Sep 15;49(18):1030-1. doi: 10.1007/BF01487734.
8
[Lymphocyte transformation in multiple sclerosis. Demonstration of cell sensitivity to basic myelin protein (author's transl)].
Klin Wochenschr. 1974 Mar 1;52(5):238-45. doi: 10.1007/BF01468597.
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Elaboration of lymphotoxin by cultured human peripheral blood leucocytes stimulated with dental-plaque deposits.用牙菌斑沉积物刺激培养的人外周血白细胞产生淋巴毒素。
Clin Exp Immunol. 1973 Mar;13(3):383-93.
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The Wiskott-Aldrich syndrome. Results of transfer factor therapy.维斯科特-奥尔德里奇综合征。转移因子治疗的结果。
J Clin Invest. 1972 Dec;51(12):3216-24. doi: 10.1172/JCI107148.