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皮肤反应、巨噬细胞游走抑制以及结核菌素活性肽(TAP)和从结核杆菌中提取的阿拉伯半乳聚糖引起的淋巴细胞转化。

Skin reaction, inhibition of macrophage migration, and lymphocyte transformation with tuberculin active peptide (TAP) and arabinogalactan obtained from tubercle bacilli.

作者信息

Niinaka T, Kishimoto S, Aoki T, Ikegami H, Ito F

出版信息

Int Arch Allergy Appl Immunol. 1975;49(5):585-96. doi: 10.1159/000231440.

DOI:10.1159/000231440
PMID:809364
Abstract

Arabinogalactan purified from heat-killed tubercle bacilli failed to elicit a delayed type of skin reaction and had no ability to induce in vitro lymphocyte blast formation in sensitized guinea pigs. It was, however, inhibitory to migration of bronchoalveolar washing cells by the indirect test, but not by the direct test, and capable of eliciting an immediate type of skin reaction and anaphylaxis when injected into sensitized guinea pigs. Tuberculin active peptide (TAP) was active in all of in vitro and in vivo cell-mediated immune responses, but not in immediate responses.

摘要

从热灭活结核杆菌中纯化得到的阿拉伯半乳聚糖未能引发迟发型皮肤反应,且在致敏豚鼠中没有诱导体外淋巴细胞母细胞形成的能力。然而,通过间接试验,它对支气管肺泡灌洗细胞的迁移有抑制作用,但直接试验则无此作用,并且当注射到致敏豚鼠体内时,它能够引发速发型皮肤反应和过敏反应。结核菌素活性肽(TAP)在所有体外和体内细胞介导的免疫反应中都有活性,但在速发型反应中则无活性。

相似文献

1
Skin reaction, inhibition of macrophage migration, and lymphocyte transformation with tuberculin active peptide (TAP) and arabinogalactan obtained from tubercle bacilli.皮肤反应、巨噬细胞游走抑制以及结核菌素活性肽(TAP)和从结核杆菌中提取的阿拉伯半乳聚糖引起的淋巴细胞转化。
Int Arch Allergy Appl Immunol. 1975;49(5):585-96. doi: 10.1159/000231440.
2
Differentiation of mycobacteria by "in vivo" and "in vitro" delayed hypersensitivity reactions.通过“体内”和“体外”迟发型超敏反应鉴别分枝杆菌。
Rev Bras Pesqui Med Biol. 1978 Jun;11(2-3):111-5.
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Delayed hypersensitivity in the guinea pig immunized with killed tubercle bacilli in adjuvant. 3. Peritoneal cell migration inhibition and macrophage cytophilic antibodies to tuberculin purified protein derivative.用佐剂中灭活结核杆菌免疫豚鼠的迟发型超敏反应。3. 腹腔细胞迁移抑制及针对结核菌素纯蛋白衍生物的巨噬细胞亲细胞抗体。
Acta Pathol Microbiol Scand B Microbiol Immunol. 1972;80(1):1-9.
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Delayed hypersensitivity in the guinea pig immunized with killed tubercle bacilli in adjuvant. 1. Development of peritoneal cell migration inhibition, skin reactions and antibodies to tuberculin purified protein derivative.用佐剂中灭活结核杆菌免疫豚鼠的迟发型超敏反应。1. 腹膜细胞迁移抑制、皮肤反应及对结核菌素纯蛋白衍生物抗体的发展。
Acta Pathol Microbiol Scand B Microbiol Immunol. 1971;79(2):275-80.
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Delayed hypersensitivity in the guinea pig immunized with killed tubercle bacilli in adjuvant. 2. The effect of tuberculin purified protein derivative concentration on the inhibition of peritoneal cell migration.用佐剂中灭活结核杆菌免疫豚鼠后的迟发型超敏反应。2. 结核菌素纯蛋白衍生物浓度对腹膜细胞迁移抑制的影响。
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The adjuvant activity of mycobacterial RNA preparations and synthetic polynucleotides for induction of delayed hypersensitivity to purified protein derivative in guinea pigs.分枝杆菌RNA制剂和合成多核苷酸对豚鼠诱导对纯化蛋白衍生物迟发型超敏反应的佐剂活性。
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Lymphokine activity in vivo in relation to circulating monocyte levels and delayed skin reactivity.体内淋巴因子活性与循环单核细胞水平及皮肤迟发型反应的关系。
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The agarose migration inhibition technique for in vitro demonstration of cell-mediated immunity in man. A review.用于体外证明人体细胞介导免疫的琼脂糖迁移抑制技术。综述。
Dan Med Bull. 1975 Jul;22(5):181-94.
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Tuberculin-active carbohydrate that induces inhibition of macrophage migration but not lymphocyte transformation.结核菌素活性碳水化合物,可诱导巨噬细胞迁移抑制,但不诱导淋巴细胞转化。
Science. 1970 Nov 6;170(3958):637-9. doi: 10.1126/science.170.3958.637.
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Comparison of lymphocyte transformation, inhibition of macrophage migration and skin tests using dialyzable and nondialyzable tuberculin fractions from Mycobacterium bovis (BCG).使用来自牛分枝杆菌(卡介苗)的可透析和不可透析结核菌素组分进行淋巴细胞转化、巨噬细胞迁移抑制及皮肤试验的比较。
J Immunol. 1971 Jul;107(1):149-53.

引用本文的文献

1
Arabinogalactan enhances virulence by suppressing host innate immune responses.阿拉伯半乳聚糖通过抑制宿主固有免疫反应来增强毒力。
Front Immunol. 2022 Aug 26;13:879775. doi: 10.3389/fimmu.2022.879775. eCollection 2022.
2
Gamma interferon production by bovine gamma delta T cells following stimulation with mycobacterial mycolylarabinogalactan peptidoglycan.用分枝杆菌的分枝菌酸阿拉伯半乳聚糖肽聚糖刺激后牛γδ T细胞产生γ干扰素。
Infect Immun. 2004 Aug;72(8):4612-8. doi: 10.1128/IAI.72.8.4612-4618.2004.