牙周病中的细胞介导免疫；细胞毒性、迁移抑制及淋巴细胞转化研究
Cell-mediated immunity in periodontal disease; cytotoxicity, migration inhibition and lymphocyte transformation studies.
作者信息
Ivanyi L, Wilton J M, Lehner T
出版信息
Immunology. 1972 Jan;22(1):141-5.
Abstract
Cultures of peripheral blood lymphocytes from patients with gingivitis or mild periodontitis were stimulated with ultrasonicates of to yield an increase of C-thymidine incorporation and of cytotoxicity against Cr-labelled chicken red cells. The cell-free supernatant from the antigen-stimulated cultures inhibited migration of guinea-pig peritoneal macrophages. In patients with severe periodontitis lymphocytes showed only weak transformation but strong cytotoxic and migration-inhibitory activity. These data suggest that cell-mediated immunity against an oral Gram-negative micro-organism plays some part in the pathogenesis of periodontal disease. The advanced stage of disease, however, revealed a dissociation between lymphocyte transformation and cytotoxicity or macrophage inhibition.
摘要
用[某种微生物]的超声裂解物刺激牙龈炎或轻度牙周炎患者的外周血淋巴细胞培养物，可使C-胸苷掺入量增加，并增强对铬标记鸡红细胞的细胞毒性。抗原刺激培养物的无细胞上清液可抑制豚鼠腹腔巨噬细胞的迁移。在重度牙周炎患者中，淋巴细胞仅表现出微弱的转化，但具有较强的细胞毒性和迁移抑制活性。这些数据表明，针对口腔革兰氏阴性微生物的细胞介导免疫在牙周病的发病机制中起一定作用。然而，在疾病的晚期，淋巴细胞转化与细胞毒性或巨噬细胞抑制之间出现了分离。
相似文献
1
2
[Lymphoblastic transformation test and clinical condition of the periodontium].[淋巴细胞转化试验与牙周组织的临床状况]
Rev Odontostomatol (Paris). 1972 Jul-Aug;19(4):315-24.
3
Lymphocyte transformation by sonicates of dental plaque in human periodontal disease.人类牙周病中牙菌斑超声裂解物引起的淋巴细胞转化
Arch Oral Biol. 1971 Sep;16(9):1117-21. doi: 10.1016/0003-9969(71)90216-0.
4
The specificity of serum factors in lymphocyte transformation in periodontal disease.牙周病中血清因子在淋巴细胞转化中的特异性。
Clin Exp Immunol. 1973 Aug;14(4):491-500.
5
The role of TG lymphocytes in cell-mediated immunity in patients with periodontal disease.TG淋巴细胞在牙周病患者细胞介导免疫中的作用。
Clin Exp Immunol. 1981 Dec;46(3):633-9.
6
Immune suppression induced by Gram-negative organisms in patients with chronic inflammatory periodontal disease.慢性炎症性牙周病患者中革兰氏阴性菌诱导的免疫抑制。
Egypt Dent J. 1986 Apr;32(2):121-9.
7
In vitro cytotoxicity of lymphocytes from patients with "acquired" and sex-linked agammaglobulinaemia.“获得性”及性连锁无丙种球蛋白血症患者淋巴细胞的体外细胞毒性
Clin Exp Immunol. 1971 Nov;9(5):603-9.
8
A role for cell-mediated immunity in the pathogenesis of periodontal disease.
Zentralbl Bakteriol Orig A. 1974;227(1-4):196-210.
9
Cell-mediated immune responses in oral disease: a review.口腔疾病中的细胞介导免疫反应：综述
J Oral Pathol. 1972;1(1):39-58.
10
The significance of serum factors in stimulation of lymphocytes from patients with periodontal disease by Veillonella alcalescens.血清因子在具核梭杆菌刺激牙周病患者淋巴细胞中的意义
Int Arch Allergy Appl Immunol. 1971;41(4):620-7. doi: 10.1159/000230554.
引用本文的文献
1
Porphyromonas gingivalis HmuY stimulates expression of Bcl-2 and Fas by human CD3+ T cells.牙龈卟啉单胞菌 HmuY 刺激人 CD3+T 细胞表达 Bcl-2 和 Fas。
BMC Microbiol. 2013 Sep 11;13:206. doi: 10.1186/1471-2180-13-206.
2
Role of archaea in human disease.古菌在人类疾病中的作用。
Front Cell Infect Microbiol. 2013 Aug 13;3:42. doi: 10.3389/fcimb.2013.00042. eCollection 2013.
3
Non-antibacterial tetracycline formulations: clinical applications in dentistry and medicine.非抗菌四环素制剂：在牙科和医学中的临床应用。
J Oral Microbiol. 2012;4. doi: 10.3402/jom.v4i0.19227. Epub 2012 Oct 12.
4
Identification and distribution of immunocompetent cells in inflamed gingiva of human chronic periodontitis.人慢性牙周炎炎症牙龈中免疫活性细胞的鉴定与分布
Infect Immun. 1983 Jul;41(1):365-74. doi: 10.1128/iai.41.1.365-374.1983.
5
Humoral immune response to oral microorganisms in periodontitis.牙周炎中对口腔微生物的体液免疫反应。
Infect Immun. 1982 Aug;37(2):499-505. doi: 10.1128/iai.37.2.499-505.1982.
6
The specificity of serum factors in lymphocyte transformation in periodontal disease.牙周病中血清因子在淋巴细胞转化中的特异性。
Clin Exp Immunol. 1973 Aug;14(4):491-500.
7
Elaboration of lymphotoxin by cultured human peripheral blood leucocytes stimulated with dental-plaque deposits.用牙菌斑沉积物刺激培养的人外周血白细胞产生淋巴毒素。
Clin Exp Immunol. 1973 Mar;13(3):383-93.
8
Blastogenesis and lymphokine synthesis by T and B lymphocytes from patients with periodontal disease.牙周病患者T淋巴细胞和B淋巴细胞的母细胞生成及淋巴因子合成
Infect Immun. 1974 Oct;10(4):844-50. doi: 10.1128/iai.10.4.844-850.1974.
9
Cell mediated immunity to herpesvirus type 1 in carcinoma and pre-cancerous lesions.癌组织及癌前病变中针对1型疱疹病毒的细胞介导免疫。
Br J Cancer Suppl. 1973 Aug;1:128-34.
10
Cell-mediated immunity and antibodies to Herpesvirus hominis type 1 in oral leukoplakia and carcinoma.口腔白斑和癌中针对1型人疱疹病毒的细胞介导免疫和抗体
Br J Cancer. 1973 May;27(5):351-61. doi: 10.1038/bjc.1973.43.
本文引用的文献
1
The in vitro cytotoxicity of human lymphocytes: the effect of metabolic inhibitors.人淋巴细胞的体外细胞毒性：代谢抑制剂的作用
Exp Cell Res. 1967 Nov;48(2):334-49. doi: 10.1016/0014-4827(67)90359-x.
2
Cytotoxic potential of stimulated human lymphocytes.活化的人淋巴细胞的细胞毒性潜力
J Exp Med. 1967 Apr 1;125(4):721-36. doi: 10.1084/jem.125.4.721.
3
4
Cell migration inhibition factor released by antigen from human peripheral lymphocytes.人外周淋巴细胞抗原释放的细胞迁移抑制因子。
Nature. 1968 Aug 17;219(5155):755-7. doi: 10.1038/219755a0.
5
Cytotoxic action of stimulated lymphocytes on allogenic and autologous erythrocytes.刺激淋巴细胞对同种异体和自体红细胞的细胞毒性作用。
Science. 1968 Apr 19;160(3825):306-9. doi: 10.1126/science.160.3825.306.
6
An in vitro assay for cellular hypersensitivity in man.一种人体细胞超敏反应的体外检测方法。
J Immunol. 1970 Jan;104(1):95-102.
7
Lymphocyte transformation by sonicates of dental plaque in human periodontal disease.人类牙周病中牙菌斑超声裂解物引起的淋巴细胞转化
Arch Oral Biol. 1971 Sep;16(9):1117-21. doi: 10.1016/0003-9969(71)90216-0.
8
Stimulation of lymphocyte transformation by bacterial antigens in patients with periodontal disease.牙周病患者中细菌抗原对淋巴细胞转化的刺激作用。
Arch Oral Biol. 1970 Nov;15(11):1089-96. doi: 10.1016/0003-9969(70)90121-4.
9
Tuberculin-active carbohydrate that induces inhibition of macrophage migration but not lymphocyte transformation.结核菌素活性碳水化合物，可诱导巨噬细胞迁移抑制，但不诱导淋巴细胞转化。
Science. 1970 Nov 6;170(3958):637-9. doi: 10.1126/science.170.3958.637.
10
Cytotoxic effects of lymphoid cells in vitro.淋巴细胞在体外的细胞毒性作用。
Adv Immunol. 1969;11:117-93. doi: 10.1016/s0065-2776(08)60479-4.
Zotero 插件