Ivanyi L, Wilton J M, Lehner T
Immunology. 1972 Jan;22(1):141-5.
Cultures of peripheral blood lymphocytes from patients with gingivitis or mild periodontitis were stimulated with ultrasonicates of to yield an increase of C-thymidine incorporation and of cytotoxicity against Cr-labelled chicken red cells. The cell-free supernatant from the antigen-stimulated cultures inhibited migration of guinea-pig peritoneal macrophages. In patients with severe periodontitis lymphocytes showed only weak transformation but strong cytotoxic and migration-inhibitory activity. These data suggest that cell-mediated immunity against an oral Gram-negative micro-organism plays some part in the pathogenesis of periodontal disease. The advanced stage of disease, however, revealed a dissociation between lymphocyte transformation and cytotoxicity or macrophage inhibition.
用[某种微生物]的超声裂解物刺激牙龈炎或轻度牙周炎患者的外周血淋巴细胞培养物，可使C-胸苷掺入量增加，并增强对铬标记鸡红细胞的细胞毒性。抗原刺激培养物的无细胞上清液可抑制豚鼠腹腔巨噬细胞的迁移。在重度牙周炎患者中，淋巴细胞仅表现出微弱的转化，但具有较强的细胞毒性和迁移抑制活性。这些数据表明，针对口腔革兰氏阴性微生物的细胞介导免疫在牙周病的发病机制中起一定作用。然而，在疾病的晚期，淋巴细胞转化与细胞毒性或巨噬细胞抑制之间出现了分离。
