由于免疫复合物中未经处理的自身IgG而实验产生的针对IgG胃蛋白酶位点的抗体。
Experimentally produced antibodies to the pepsin site of IgG due to untreated autologous IgG in immune complexes.
作者信息
Mellbye O J, Natvig J B
出版信息
Clin Exp Immunol. 1970 Aug;7(2):257-67.
Abstract
By immunizing rabbits with immune precipitates containing autologous IgG as the antibody part, most animals produced both rheumatoid factor-like antibodies and antibodies to human and rabbit F(ab') IgG. The latter antibodies resembled the human antibodies to the pepsin site of IgG by not reacting with untreated IgG and by reacting with immune precipitates made from autologous and homologous antibodies. The rabbit antibodies to the pepsin site of IgG in most cases consisted of a mixture of IgG and IgM, while the human antibody is usually pure IgG. The investigation demonstrated that in addition to rheumatoid factor, other human anti-IgG antibodies may also be due to antigenic stimulation by autologous IgG in immune complexes.
摘要
通过用含有自体IgG作为抗体部分的免疫沉淀物免疫兔子，大多数动物产生了类风湿因子样抗体以及针对人及兔F(ab')IgG的抗体。后一种抗体与未处理的IgG不反应，且与由自体和同源抗体形成的免疫沉淀物反应，这类似于人针对IgG胃蛋白酶位点的抗体。在大多数情况下，兔针对IgG胃蛋白酶位点的抗体由IgG和IgM的混合物组成，而人抗体通常是纯IgG。该研究表明，除类风湿因子外，其他人类抗IgG抗体也可能是由于免疫复合物中自体IgG的抗原刺激所致。
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