Mellbye O J, Naes B, Munthe E
Ann Rheum Dis. 1976 Jun;35(3):233-9. doi: 10.1136/ard.35.3.233.
In order to see if the complement (C) consumption and conversion, which are typical of rheumatoid joints, continue after synovectomy, 23 knee joints in which synovectomy had been performed from 4-5 to 6-5 years previously, were studied. The mean ratio of the concentration of C3, C4, and C5 in synovial fluid to that in palsma of the same patient was significantly lower than the corresponding ratio for the total protein content. This was found both in joints with active arthritis and in joints without clinical signs of arthritis, and in both seropositive and seronegative patients. Conversion products of C3 were found in 7 of the synovial fluids. The study thus indicated that the complement alterations in synovectomized joints are very similar to those in nonsynovectomized rheumatoid joints. In one synovial fluid agarose electrophoresis showed multiple sharp bands in the gamma region. By crossed immunoelectrophoresis some bands seemed to contain IgG with one type of light chains only. In plasma of the same patients the bands were much weaker, indicating local production of oligoclonal IgG in the joint.
为了观察类风湿关节典型的补体（C）消耗和转化在滑膜切除术后是否继续存在，对23个膝关节进行了研究，这些膝关节在4至5年前至6至5年前进行了滑膜切除术。同一患者滑膜液中C3、C4和C5浓度与血浆中浓度的平均比值显著低于总蛋白含量的相应比值。这在有活动性关节炎的关节和无关节炎临床体征的关节中均有发现，在血清阳性和血清阴性患者中也均如此。在7份滑膜液中发现了C3的转化产物。该研究表明，滑膜切除术后关节中的补体改变与未进行滑膜切除术的类风湿关节中的补体改变非常相似。在一份滑膜液中，琼脂糖电泳在γ区显示出多条清晰的条带。通过交叉免疫电泳，一些条带似乎仅含有一种轻链的IgG。在同一患者的血浆中，这些条带要弱得多，表明关节中存在寡克隆IgG的局部产生。
