类风湿性滑膜组织中的类风湿因子斑块形成细胞。
Rheumatoid factor plaque-forming cells in rheumatoid synovial tissue.
作者信息
Taylor-Upsahl M M, Abrahamsen T G, Natvig J B
出版信息
Clin Exp Immunol. 1977 May;28(2):197-203.
Abstract
Cells producing rheumatoid factor (RF) were readily detected in vitro by means of a haemolytic plaque assay system employing sheep erythrocytes (SRBC) sensitized with reduced and alkylated rabbit IgG anti-SRBC antibody as target cells. Rheumatoid factor-producing, plaque-forming cells (RF-PFC) were observed in all of the synovial tissue cell preparations from seropositive rheumatoid arthritis patients studied. The numbers of RF-PFC varied considerably without any direct correlation with serum titres of RF antibody activity. However, high numbers of RF-PFC were never found in patients with low rheumatoid factor titres whereas, high and low numbers of RF-PFC were found among the patients with high RF titres. Synovial tissue cell preparations from a group of seronegative patients, with only one exception, failed to exhibit RF-PFC.
摘要
通过采用用还原和烷基化的兔IgG抗绵羊红细胞（SRBC）抗体致敏的绵羊红细胞（SRBC）作为靶细胞的溶血空斑测定系统，可在体外轻松检测出产生类风湿因子（RF）的细胞。在所研究的血清阳性类风湿性关节炎患者的所有滑膜组织细胞制剂中均观察到产生类风湿因子的空斑形成细胞（RF-PFC）。RF-PFC的数量差异很大，与RF抗体活性的血清滴度没有任何直接相关性。然而，类风湿因子滴度低的患者中从未发现大量的RF-PFC，而在RF滴度高的患者中则发现了数量多和数量少的RF-PFC。一组血清阴性患者的滑膜组织细胞制剂，只有一例例外，未表现出RF-PFC。
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