Parrott D M, De Sousa M A, Fachet J, Wallis V, Leuchars E, Davies A J
Clin Exp Immunol. 1970 Sep;7(3):387-93.
Normal, deprived' (thymectomized, irradiated, bone marrow injected) and
reconstituted' (thymectomized, irradiated, bone marrow injected, thymus grafted) CBA mice have been tested for their ability to respond to the contact sensitizing agent, oxazolone. The test involved painting the ear of a previously sensitized animal and subsequently measuring alterations in ear thickness. A sensitized condition could be detected in the normal and reconstituted mice after either one or two sensitizing contacts with oxazolone but in the deprived animal little or no sensitivity could be detected. It is concluded that the thymus influences the development of contact sensitivity probably by provision of a population of reactive cells.
对正常的、“去胸腺”(胸腺切除、照射、注射骨髓)和“重建”(胸腺切除、照射、注射骨髓、移植胸腺)的CBA小鼠进行了测试,以检测它们对接触致敏剂恶唑酮的反应能力。测试包括给先前致敏的动物耳部涂抹药物,随后测量耳部厚度的变化。在与恶唑酮进行一次或两次致敏接触后,正常小鼠和重建小鼠中均可检测到致敏状态,但在去胸腺动物中几乎检测不到或根本检测不到敏感性。结论是胸腺可能通过提供一群反应性细胞来影响接触敏感性的发展。