着色性干皮病切除缺陷型中的第七个互补群。
A seventh complementation group in excision-deficient xeroderma pigmentosum.
作者信息
Keijzer W, Jaspers N G, Abrahams P J, Taylor A M, Arlett C F, Zelle B, Takebe H, Kinmont P D, Bootsma D
出版信息
Mutat Res. 1979 Aug;62(1):183-90. doi: 10.1016/0027-5107(79)90231-8.
Cells from a xeroderma pigmentosum patient XP2BI who has reached 17 years of age with no keratoses or skin tumours constitute a new, 7th complementation group G. These cells exhibit a low residual level of excision repair, 2% of normal after a UV dose of 5 J/m2 and an impairment of post-replication repair characteristic of excision-defective XPs. They are also sensitive to the lethal effects of UV and defective in host-cell reactivation of UV-irradiated SV40 DNA.
来自一名17岁的着色性干皮病患者XP2BI的细胞，没有角化病或皮肤肿瘤，构成了一个新的第7个互补组G。这些细胞表现出低水平的残余切除修复能力，在紫外线剂量为5 J/m2后为正常水平的2%，并且具有切除缺陷型着色性干皮病典型的复制后修复损伤。它们对紫外线的致死效应也敏感，并且在紫外线照射的SV40 DNA的宿主细胞再激活方面存在缺陷。
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