Ruggiero G, Spadacenta F, Gargiulo M, Miraglia E, Gianturco G
Minerva Med. 1979 Sep 29;70(42):2863-7.
The prevalence of cryoglobulinaemia in a series of patients with chronic liver disease from the Campania area has been studied. The series included: 14 cases of chronic persistent hepatitis (CPH), 70 cases of chronic active hepatitis (CAH) and 113 cases of liver cirrhosis. Liver function tests were carried out on the serum of each patient and cryoglobulines were studied. Liver biopsy was carried out when indicated. About a third of the patients were under the effect of previous treatment with anti-inflammatory steroids and-or azathioprine. Cryoglobulines were found in 4 of the 197 patients (2%); of type IgG in 3 cases: 1 of CAH, HBsAg negative and 2 of inactive cirrhosis of which one with HbsAg in the serum; of type IgM in 1 case of CAH, HBsAg negative. The data are discussed on relation to other reported data.
对坎帕尼亚地区一系列慢性肝病患者的冷球蛋白血症患病率进行了研究。该系列包括：14例慢性持续性肝炎（CPH）、70例慢性活动性肝炎（CAH）和113例肝硬化。对每位患者的血清进行肝功能检查并研究冷球蛋白。在有指征时进行肝活检。约三分之一的患者曾接受过抗炎类固醇和/或硫唑嘌呤治疗。197例患者中有4例（2%）发现冷球蛋白；3例为IgG型：1例为CAH，HBsAg阴性，2例为非活动性肝硬化，其中1例血清中有HbsAg；1例为CAH，HBsAg阴性，为IgM型。结合其他报告的数据对这些数据进行了讨论。
