以质粒形式持续存在的λ突变体。
Lambda mutants which persist as plasmids.
作者信息
Lieb M
出版信息
J Virol. 1970 Aug;6(2):218-25. doi: 10.1128/JVI.6.2.218-225.1970.
Abstract
Lambda phages mutated in gene N do not kill sensitive host bacteria, but persist as plasmids. Plasmids are formed by genomes containing cI(+), and also by sus, ts, or c mutants of cI. Bacteria infected with two or more phage particles give rise to clones in which most of the bacteria are carriers. The introduced lambda genomes replicate more than once per bacterial division until there are 10 to 20 lambda plasmids per host genome. In bacteria containing both F and lambda plasmids, both replicate independently, and elimination by growth in acridine orange is also independent. Carriers of lambda Nsus plasmids are not immune, and there is complementation between the plasmids and superinfecting lambda mutants.
摘要
在基因N中发生突变的λ噬菌体不会杀死敏感宿主细菌，而是以质粒形式持续存在。质粒由含有cI(+)的基因组形成，也由cI的sus、ts或c突变体形成。被两个或更多噬菌体颗粒感染的细菌会产生克隆，其中大多数细菌是携带者。引入的λ基因组在每个细菌分裂周期中复制不止一次，直到每个宿主基因组中有10到20个λ质粒。在同时含有F和λ质粒的细菌中，两者都独立复制，并且通过在吖啶橙中生长进行消除也是独立的。λNsus质粒的携带者没有免疫力，并且质粒与超感染的λ突变体之间存在互补作用。
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