Soll D B, Harrison S E
Ophthalmic Surg. 1979 Aug;10(8):31-6.
In cryosurgery, a rapid double freeze using liquid nitrogen spray coupled with a slow thaw generates optimum cell destruction. Important factors in using the cryosurgical technique include temperature monitoring of the lesion, the type of instrumentation, the type of cryogen, and the nonhomogeneity of human tissue. Physiological processes occurring subsequent to cryogen application cause tissue necrosis. Cryosurgery is indicated for treatment of some basal cell carcinomas and occasional squamous cell carcinomas; most other lesions should be treated by surgical excision at the present time. The authors are involved in research to determine means of observing tissue destruction, temperature monitoring and control methods, and evaluation of post-thawing processes.
在冷冻手术中，使用液氮喷雾进行快速双重冷冻并缓慢解冻可产生最佳的细胞破坏效果。使用冷冻手术技术的重要因素包括对病变部位的温度监测、器械类型、冷冻剂类型以及人体组织的不均匀性。应用冷冻剂后发生的生理过程会导致组织坏死。冷冻手术适用于治疗某些基底细胞癌和偶尔的鳞状细胞癌；目前，大多数其他病变应通过手术切除进行治疗。作者们正在参与研究，以确定观察组织破坏的方法、温度监测和控制方法以及解冻后过程的评估。
