用人源抗体对大鼠胃壁细胞进行免疫荧光染色，该抗体与恶性贫血无关。

Immunofluorescent staining of rat gastric parietal cells by human antibody unrelated to pernicious anaemia.

作者信息

Muller H K, McGiven A R, Nairn R C

出版信息

J Clin Pathol. 1971 Feb;24(1):13-4. doi: 10.1136/jcp.24.1.13.

DOI:10.1136/jcp.24.1.13

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC478006/

Abstract

Immunofluorescence tests on 94 human sera reacting with rat gastric parietal cells revealed that 41 (44%) of the sera contained antibody to a rat parietal cell antigen that was distinct from the pernicious anaemia autoantigen. Ten of the sera contained antibodies to both parietal cell antigens. The remaining 53 (56%) sera contained only parietal cell antibodies of the pernicious anaemia type. We recommend that mouse gastric mucosa, which does not react with the heterologous rat parietal cell antibody, replace rat gastric mucosa for immunofluorescence diagnostic tests.

摘要

对94份与大鼠胃壁细胞发生反应的人血清进行免疫荧光检测，结果显示，其中41份（44%）血清含有针对一种与恶性贫血自身抗原不同的大鼠壁细胞抗原的抗体。10份血清含有针对两种壁细胞抗原的抗体。其余53份（56%）血清仅含有恶性贫血型壁细胞抗体。我们建议，在免疫荧光诊断检测中，用不与异种大鼠壁细胞抗体发生反应的小鼠胃黏膜替代大鼠胃黏膜。

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本文引用的文献

1

PERNICIOUS ANAEMIA AUTOANTIBODY TO GASTRIC PARIETAL CELLS: IMMUNOFLUORESCENCE TEST WITH RAT STOMACH.恶性贫血胃壁细胞自身抗体：用大鼠胃进行免疫荧光试验。

J Clin Pathol. 1965 Jul;18(4):456-9. doi: 10.1136/jcp.18.4.456.

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