Bloom A L, Beck P, Giddings J C, Sweetnam P M
J Clin Pathol. 1971 Feb;24(1):23-6. doi: 10.1136/jcp.24.1.23.
Coagulation studies were performed on haemophilic patients during a controlled trial of oral contraceptive therapy. Treatment with a combined oestrogen-progestogen preparation was associated with a significant rise in the factor VII-X complex. This change was not observed during treatment with progestogen alone. The highest levels of factor IX and fibrinogen and the lowest levels of factor X were observed during the first period of the trial but these effects were independent of the type of treatment. The results suggest that the effects of oral contraceptives on blood coagulation in haemophilic males are similar to those observed in normal females and that the changes are due to the oestrogenic component.
在一项口服避孕药治疗的对照试验中，对血友病患者进行了凝血研究。联合使用雌激素 - 孕激素制剂治疗与因子VII - X复合物显著升高有关。单独使用孕激素治疗期间未观察到这种变化。在试验的第一阶段观察到因子IX和纤维蛋白原的最高水平以及因子X的最低水平，但这些影响与治疗类型无关。结果表明，口服避孕药对血友病男性血液凝固的影响与正常女性中观察到的相似，并且这些变化是由雌激素成分引起的。
