炔诺酮口服孕激素避孕药对血液凝固和血小板的影响。
Effects of progestogen oral contraception with norethisterone on blood clotting and platelets.
作者信息
Poller L, Thomson J M, Thomas P W
出版信息
Br Med J. 1972 Nov 18;4(5837):391-3. doi: 10.1136/bmj.4.5837.391.
Abstract
The effects on clotting tests and platelet function of six months' continuous administration of the 19-norsteroid, progestogen-only contraceptive, norethisterone, have been studied in four groups of women. In a group of women who have not previously taken oral contraceptive no acceleration of clotting or platelet factors was found, but in contrast a tendency to reduced coagulability was observed. Women who had previously been taking combined oestrogen-progestogen preparations showed reduced clotting and platelet parameters when norethisterone was substituted. No changes in clotting or platelets were found in women who changed from 17-acetoxysteroid progestogen chloramadinone acetate or in a group of women started postpartum.
摘要
在四组女性中研究了连续六个月服用19-去甲甾体、仅含孕激素的避孕药炔诺酮对凝血试验和血小板功能的影响。在一组此前未服用过口服避孕药的女性中，未发现凝血或血小板因子加速，但相反，观察到有凝血性降低的趋势。此前一直在服用雌激素-孕激素复方制剂的女性，改用炔诺酮后凝血和血小板参数降低。从17-乙酰氧基甾体孕激素醋酸氯地孕酮改用炔诺酮的女性，以及产后开始服药的一组女性，凝血或血小板均未出现变化。
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