前列腺素及其类似物XXIII（1）。15-脱氧-16-羟基-16-甲基前列腺素的合成。C13 - C14反式双键对支气管扩张活性的重要性。
Prostaglandins and congeners XXIII (1). Synthesis of 15-deoxy-16-hydroxy-16-methylprostanglandins. The importance of the C13--C14 trans double bond for bronchodilator activity.
作者信息
Chen S M, Grudzinskas C V, Dessy F
出版信息
Prostaglandins. 1979 May;17(5):707-17. doi: 10.1016/s0090-6980(79)80042-8.
PMID:493558
Abstract
The synthesis and bronchodilator activity in the guinea pig of several 15-deoxy-16-hydroxy-16-methylprostaglandin analogs is described. The E2 (VIa) and E1 (VIb) analogs are potent bronchodilators comparable in activity to the natrual prostaglandins, but possessing a longer duration of effect. Replacement of the C13--C14 trans double bond by a cis double bond or an ethylene linkage causes a substantial diminishment of this activity.
摘要
本文描述了几种15-脱氧-16-羟基-16-甲基前列腺素类似物在豚鼠体内的合成及其支气管扩张活性。E2（VIa）和E1（VIb）类似物是强效支气管扩张剂，其活性与天然前列腺素相当，但作用持续时间更长。将C13 - C14反式双键替换为顺式双键或乙烯键会导致这种活性大幅降低。
相似文献
1
Prostaglandins and congeners XXIII (1). Synthesis of 15-deoxy-16-hydroxy-16-methylprostanglandins. The importance of the C13--C14 trans double bond for bronchodilator activity.前列腺素及其类似物XXIII（1）。15-脱氧-16-羟基-16-甲基前列腺素的合成。C13 - C14反式双键对支气管扩张活性的重要性。
Prostaglandins. 1979 May;17(5):707-17. doi: 10.1016/s0090-6980(79)80042-8.
2
Prostaglandins and congeners. 22. Synthesis of 11-substituted derivatives of 11-deoxyprostaglandins E1 and E2. Potential bronchodilators.前列腺素及其类似物。22. 11-脱氧前列腺素E1和E2的11-取代衍生物的合成。潜在的支气管扩张剂。
J Med Chem. 1980 Aug;23(8):903-13. doi: 10.1021/jm00182a018.
3
Prostaglandins and congeners. 15. Synthesis and bronchodilator activity of dl-11-deoxy-15- or 16-alkylprostaglandins.前列腺素及其类似物。15. dl-11-脱氧-15-或16-烷基前列腺素的合成与支气管扩张活性
J Med Chem. 1977 Dec;20(12):1551-7. doi: 10.1021/jm00222a003.
4
Azaprostaglandins. Synthesis and antiulcer activity of 11-deoxy-8-azaprostaglandin analogues.氮杂前列腺素。11-脱氧-8-氮杂前列腺素类似物的合成及抗溃疡活性。
Farmaco Sci. 1983 Jul;38(7):498-507.
5
Prostaglandins and congeners. 16. Synthesis and bronchodilator activity of dl-11-doexy-3-thiaprostaglandins.前列腺素及其类似物。16. 外消旋-11-脱氧-3-硫代前列腺素的合成及支气管扩张活性
J Med Chem. 1977 Dec;20(12):1662-5. doi: 10.1021/jm00222a024.
6
11-Deoxy-11 alpha,12 alpha-methanoprostaglandin E2, a potent, short-acting bronchodilator.11-脱氧-11α,12α-甲撑前列腺素E2，一种强效短效支气管扩张剂。
J Pharm Sci. 1986 Mar;75(3):307-12. doi: 10.1002/jps.2600750322.
7
Synthesis and gastric antisecretory properties of 4,5-unsaturated derivatives of 15-deoxy-16-hydroxy-16-methylprostaglandin E1.15-脱氧-16-羟基-16-甲基前列腺素E1的4,5-不饱和衍生物的合成及其胃抗分泌特性
J Med Chem. 1983 Jun;26(6):786-90. doi: 10.1021/jm00360a002.
8
Studies on prostaglandins. VI. Synthesis of 16(S)-methyl-20-methoxy-PGE2 (YPG-209) having oral bronchodilator activity and its analogs.前列腺素研究。VI. 具有口服支气管扩张活性的16(S)-甲基-20-甲氧基-PGE2（YPG-209）及其类似物的合成。
Chem Pharm Bull (Tokyo). 1980 May;28(5):1422-31. doi: 10.1248/cpb.28.1422.
9
Structure activity studies leading to a tissue-selective hypotensive prostaglandin analog, 13,14-dihydro-16-phenyl-omega-tetranor PGE2.结构活性研究导向一种组织选择性降压前列腺素类似物，13,14-二氢-16-苯基-ω-四降前列环素E2。
Prostaglandins. 1980 Sep;20(3):515-20. doi: 10.1016/0090-6980(80)90039-8.
10
Synthesis of a trans-hydrindane nuclear analog of 11-desoxy-dihydro-prostaglandin E1.11-脱氧-二氢-前列腺素E1的反式氢化茚核类似物的合成。
Prostaglandins. 1978 Jul;16(1):79-83. doi: 10.1016/0090-6980(78)90203-4.
Zotero 插件