白血病和正常小鼠血清中一种可滤过因子诱导骨髓集落刺激活性
Induction of bone marrow colony-stimulating activity by a filterable agent in leukemic and normal mouse serum.
作者信息
Foster R, Metcalf D, Kirchmyer R
出版信息
J Exp Med. 1968 May 1;127(5):853-66. doi: 10.1084/jem.127.5.853.
Abstract
- Leukemic Swiss mice of ICR/Ha strain which had been injected at birth with a lymphoid-leukemia-inducing virus preparation yielded sera which produced elevations of serum colony-stimulating activity within 16 hr and significant plasma-LDH-enzyme elevation at 4 days when injected intraperitoneally into normal ICR/Ha Swiss mice. Colony-stimulating activity was assayed in vitro by the stimulation of hemopoietic colony formation by DBA/1 bone marrow cells. 2. The inducing agent in leukemic serum was passageable, filterable, sedimentable, and heat-, ether-, and UV-labile. 3. A similar agent was recovered from normal Swiss serum after blind serial passages through normal mice. 4. LDH elevating virus induced a similar elevation of serum colony-stimulating activity when injected at high titers, and cross-resistance was demonstrated between LDH virus and the passaged leukemic serum agent.
摘要
- ICR/Ha品系的白血病瑞士小鼠在出生时注射了一种诱导淋巴细胞白血病的病毒制剂，其血清在腹腔注射到正常ICR/Ha瑞士小鼠体内后，16小时内血清集落刺激活性升高，4天时血浆乳酸脱氢酶（LDH）酶显著升高。集落刺激活性通过DBA/1骨髓细胞刺激造血集落形成在体外进行测定。2. 白血病血清中的诱导剂可传代、可过滤、可沉淀，且对热、乙醚和紫外线不稳定。3. 在通过正常小鼠进行盲目连续传代后，从正常瑞士血清中回收了一种类似的因子。4. 高滴度注射时，LDH升高病毒诱导血清集落刺激活性出现类似升高，并且在LDH病毒和传代的白血病血清因子之间表现出交叉抗性。
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