在缺乏脱氧核糖核酸合成的情况下，丝裂霉素C与大肠杆菌素B的温度诱导
Mitomycin C and temperature induction of colicin B in the absence of deoxyribonucleic acid synthesis.
作者信息
Hausmann C, Clowes R C
出版信息
J Bacteriol. 1971 Sep;107(3):633-5. doi: 10.1128/jb.107.3.633-635.1971.
Abstract
An Escherichia coli K-12 strain and its mutant, temperature-sensitive in deoxyribonucleic acid (DNA) synthesis, were used as hosts for two different ColB factors (ColB3-K166 and ColB4-K98). Induction of either colicin occurred in both hosts in the presence of mitomycin C at 42 C. Induction of the temperature-sensitive colicinogenic hosts also occurred without mitomycin C at 42 C at which temperature no DNA synthesis was observed. Colicin synthesis was a nonlethal event in ColB4-K98(+) cultures, whereas in cultures of ColB3-K166(+) induction led to death of a large fraction of the population.
摘要
一株大肠杆菌K-12菌株及其在脱氧核糖核酸（DNA）合成中对温度敏感的突变体，被用作两种不同的ColB因子（ColB3-K166和ColB4-K98）的宿主。在42℃下，丝裂霉素C存在时，两种宿主中均会发生任何一种大肠杆菌素的诱导。对温度敏感的产大肠杆菌素宿主在42℃下，即使没有丝裂霉素C也会发生诱导，而在该温度下未观察到DNA合成。在ColB4-K98(+)培养物中，大肠杆菌素合成是一个非致死事件，而在ColB3-K166(+)培养物中，诱导导致大部分群体死亡。
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