Dempsey W B, Arcement L J
J Bacteriol. 1971 Aug;107(2):580-2. doi: 10.1128/jb.107.2.580-582.1971.
An Escherichia coli mutant resistant to isoniazid (WG497) contained 0.6 mumole of extracellular pyridoxamine and pyridoxamine phosphate in the early stationary phase. A suppressed lysine mutant (AT1024) contained 1.4 mumoles of pyridoxal phosphate under the same conditions. The internal concentration of vitamin B(6) was one-half of normal for AT1024 and increased fivefold for WG497.
一株对异烟肼耐药的大肠杆菌突变体(WG497)在稳定期早期含有0.6微摩尔细胞外吡哆胺和磷酸吡哆胺。一株赖氨酸抑制突变体(AT1024)在相同条件下含有1.4微摩尔磷酸吡哆醛。对于AT1024,维生素B6的细胞内浓度是正常浓度的一半,而对于WG497则增加了五倍。