Sabri S, Roberts V C, Cotton L T
Br Med J. 1971 Nov 13;4(5784):394-6. doi: 10.1136/bmj.4.5784.394.
A clinical trial is described in which the effect of intermittent compression of the lower limb during surgery on the incidence of early postoperative deep vein thrombosis was assessed. Deep vein thromboses were diagnosed by the (125)I-fibrinogen uptake test. Peroperative intermittent compression was achieved by means of an inflatable plastic splint coupled to a pneumatic controller. By compressing only one leg of each patient, each patient acted as his own control.With a sequential statistical analysis, 39 patients were required to pass the 5% level of significance. Eleven thrombi were detected in the control (uncompressed) legs and two occurred in the compressed legs; one of the latter was bilateral. The investigation shows that increasing the pulsatility of the venous flow in the leg is a potent prophylactic against postoperative deep vein thrombosis.
本文描述了一项临床试验，旨在评估手术期间下肢间歇性压迫对术后早期深静脉血栓形成发生率的影响。深静脉血栓通过（125）I-纤维蛋白原摄取试验进行诊断。术中通过与气动控制器相连的可充气塑料夹板实现间歇性压迫。通过仅对每位患者的一条腿进行压迫，每位患者自身作为对照。采用序贯统计分析，需要39例患者才能达到5%的显著性水平。在对照（未受压）腿中检测到11个血栓，受压腿中出现2个血栓；其中1个受压腿的血栓为双侧性。该研究表明，增加腿部静脉血流的搏动性是预防术后深静脉血栓形成的有效措施。
