Rubin A S, Coons A H
Proc Natl Acad Sci U S A. 1971 Aug;68(8):1665-9. doi: 10.1073/pnas.68.8.1665.
In suspension cultures of mouse spleen cells, the addition of small amounts (1-100 ng) of a heterologous antigen to which the donor mice had been primed significantly increased the number of anti-sheep erythrocyte plaques appearing after stimulation with sheep erythrocytes. A similar addition to identical cultures from unprimed donors produced a small depression in the number of such plaques.
在小鼠脾细胞的悬浮培养物中,向已致敏的供体小鼠添加少量(1 - 100纳克)的异种抗原,在用绵羊红细胞刺激后,显著增加了抗绵羊红细胞噬斑的数量。向未致敏供体的相同培养物中添加类似物质,会使此类噬斑数量略有减少。