MacDonald A B, Fraser C E, Rubin A S
Immunology. 1978 Jan;34(1):137-47.
Herpesvirus saimiri inoculated into owl monkeys (Aotus trivirgatus) causes leukaemia and lymphoma. Peripheral lymphocytes from leukaemic monkeys grown in culture are predominantly T lymphocytes. The supernatants from these cultures contain a factor which enhances the antibody response of murine B cells to sheep red blood cells (SRBC). The factor has been partially characterized by ammonium sulphate precipitation, DEAE-chromatography, gel filtration over Sephadex G-150 and disc-gel electrophoresis. The enhancing factor is a protein with a molecular weight of approximately 40,000.
接种到夜猴(Aotus trivirgatus)体内的赛米利疱疹病毒会引发白血病和淋巴瘤。在培养中生长的白血病猴的外周淋巴细胞主要是T淋巴细胞。这些培养物的上清液中含有一种可增强鼠B细胞对绵羊红细胞(SRBC)抗体反应的因子。该因子已通过硫酸铵沉淀、DEAE色谱法、Sephadex G - 150凝胶过滤和圆盘凝胶电泳进行了部分特性鉴定。增强因子是一种分子量约为40,000的蛋白质。