激素甾体与氨酰基转移核糖核酸的选择性关联及蛋白质合成的调控
Selective associations of hormonal steroids with aminoacyl transfer RNAs and control of protein synthesis.
作者信息
Chin R C, Kidson C
出版信息
Proc Natl Acad Sci U S A. 1971 Oct;68(10):2448-52. doi: 10.1073/pnas.68.10.2448.
Abstract
The hormonal steroids progesterone, estradiol, testosterone, and 5alpha-dihydrotestosterone bind to aminoacyl-tRNA, but not to deacylated tRNA, implying that a change in conformation of tRNA occurs on aminoacylation. Binding is restricted to a few tRNA species and depends on the structure of both tRNA and steroid. There is one binding site per aminoacyl-tRNA molecule, the specificity of which appears to depend on a restricted, single-stranded loop sequence and on the tRNA conformation. By binding to an aminoacyl-tRNA, a steroid can control polypeptide synthesis in a model in vitro system by inhibiting chain elongation under conditions where aminoacyl-tRNA concentration is rate-limiting.
摘要
激素甾体类物质孕酮、雌二醇、睾酮和5α-二氢睾酮与氨酰基-tRNA结合，但不与去酰基化tRNA结合，这意味着tRNA的构象在氨酰化过程中会发生变化。这种结合仅限于少数几种tRNA，并且取决于tRNA和甾体的结构。每个氨酰基-tRNA分子有一个结合位点，其特异性似乎取决于一个受限的单链环序列和tRNA的构象。通过与氨酰基-tRNA结合，甾体在体外模型系统中，在氨酰基-tRNA浓度为限速因素的条件下，通过抑制链延伸来控制多肽合成。
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Selective associations of hormonal steroids with aminoacyl transfer RNAs and control of protein synthesis.激素甾体与氨酰基转移核糖核酸的选择性关联及蛋白质合成的调控
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