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通过免疫重建治疗慢性黏膜皮肤念珠菌病。

Treatment of chronic mucocutaneous moniliasis by immunologic reconstitution.

作者信息

Kirkpatrick C H, Rich R R, Graw R G, Smith T K, Mickenberg I, Rogentine G N

出版信息

Clin Exp Immunol. 1971 Dec;9(6):733-48.

PMID:4945734
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1713127/
Abstract

The immunological defect in a patient with chronic mucocutaneous moniliasis was characterized. While his Candida skin test was negative. exposure of his lymphocytes to candida extracts produced an increase in thymidine incorporation. Supernatants from cultures of antigen-stimulated lymphocytes did not contain macrophage migration-inhibition factor (MIF) activity. Restoration of the immune system with transfusions of immuno-competent allogeneic lymphocytes was accompanied by conversion of the Candida skin test to positive, and MIF production by his lymphocytes. During the period that his immune system remained intact, there was marked clearing of the moniliasis. Eight months following the transfusions, the moniliasis recurred and when restudied, the patient again had negative skin tests and insignificant MIF production. These observations demonstrate the importance of mediators in the expression of delayed hypersensitivity and provide evidence of a role of cellular immunity in resistance to certain chronic fungal infections.

摘要

对一名慢性黏膜皮肤念珠菌病患者的免疫缺陷进行了特征描述。虽然他的念珠菌皮肤试验呈阴性，但将其淋巴细胞暴露于念珠菌提取物中会使胸腺嘧啶核苷掺入增加。抗原刺激淋巴细胞培养物的上清液不含有巨噬细胞移动抑制因子（MIF）活性。用具有免疫活性的同种异体淋巴细胞输血恢复免疫系统后，念珠菌皮肤试验转为阳性，且其淋巴细胞产生MIF。在其免疫系统保持完整的期间，念珠菌病有明显的消退。输血八个月后，念珠菌病复发，再次检查时，患者的皮肤试验又呈阴性，且MIF产生极少。这些观察结果证明了介质在迟发型超敏反应表达中的重要性，并为细胞免疫在抵抗某些慢性真菌感染中的作用提供了证据。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/99d2/1713127/0a93dbb44b83/clinexpimmunol00373-0040-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/99d2/1713127/4e0517fe0049/clinexpimmunol00373-0038-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/99d2/1713127/b5f097a5b7dd/clinexpimmunol00373-0038-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/99d2/1713127/f5fc2747307b/clinexpimmunol00373-0039-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/99d2/1713127/3384674059c2/clinexpimmunol00373-0039-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/99d2/1713127/0a93dbb44b83/clinexpimmunol00373-0040-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/99d2/1713127/4e0517fe0049/clinexpimmunol00373-0038-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/99d2/1713127/b5f097a5b7dd/clinexpimmunol00373-0038-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/99d2/1713127/f5fc2747307b/clinexpimmunol00373-0039-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/99d2/1713127/3384674059c2/clinexpimmunol00373-0039-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/99d2/1713127/0a93dbb44b83/clinexpimmunol00373-0040-a.jpg

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引用本文的文献

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A THREE-CELL INTERACTION REQUIRED FOR THE INDUCTION OF THE PRIMARY IMMUNE RESPONSE in vitro.体外诱导初次免疫反应所需的三细胞相互作用。
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The susceptibility to moniliasis in children with endocrine hypofunction.内分泌功能减退患儿对念珠菌病的易感性。
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One-way stimulation in mixed leukocyte cultures.混合白细胞培养中的单向刺激。
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Moniliasis--an internal disease? Three cases of idiopathic hypoparathyroidism with moniliasis, steatorrhea, primary amenorrhea and pernicious anemia.
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Chronic mucocutaneous candidiasis as a surface expression of deep-seated abnormalities. Report of a syndrome of superficial candidiasis, absence of delayed hypersensitivity and aminoaciduria.慢性黏膜皮肤念珠菌病作为深部异常的一种表面表现。浅表念珠菌病、迟发型超敏反应缺失及氨基酸尿综合征的报告。
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