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[视觉功能受损恢复过程中运动皮层神经元的谷氨酸脱氢酶活性]

[Glutamate dehydrogenase activity in motor cortex neurons during restoration of disrupted visual function].

作者信息

Busniuk M M

出版信息

Zh Vyssh Nerv Deiat Im I P Pavlova. 1979 Sep-Oct;29(5):1061-6.

PMID:494783
Abstract

The recovery of the visual function of rats throughout two weeks after deprivation period (keeping animals in dark chambers for 8 weeks from their birth) leads to a significant normalization of the activity level of glutomatedehydrogenase in the neurones of the III and V layers of the motor cortex. The changes of the enzyme activity in the neurones are accompanied by a diminution of their sizes. The obtained data together with the results of the previous studies (Busnuk, 1976), suggest that the elimination of the visual impulse activity in the early ontogenesis exerts a specific and reversible influence on the morpho-chemical differentiation of neurones both in the visual and in the motor cortical areas. The functional factors determining the direction of changes in the studied parameters of cortical neurones during deprivation and in the rate of their normalization during recovery of the visual function are discussed.

摘要

在剥夺期(从出生起将动物置于黑暗室中8周)后的两周内,大鼠视觉功能的恢复导致运动皮层III层和V层神经元中谷氨酸脱氢酶活性水平显著正常化。神经元中酶活性的变化伴随着其大小的减小。获得的数据与先前研究(Busnuk,1976)的结果一起表明,在个体发育早期消除视觉冲动活动对视觉和运动皮层区域神经元的形态化学分化产生特定且可逆的影响。讨论了决定剥夺期间皮层神经元研究参数变化方向及其在视觉功能恢复期间正常化速率的功能因素。

相似文献

1
[Glutamate dehydrogenase activity in motor cortex neurons during restoration of disrupted visual function].[视觉功能受损恢复过程中运动皮层神经元的谷氨酸脱氢酶活性]
Zh Vyssh Nerv Deiat Im I P Pavlova. 1979 Sep-Oct;29(5):1061-6.
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[Changes in glutamate dehydrogenase activity in the neurons of the motor cortexof the cerebral hemispheres during light deprivation].[光剥夺期间大脑半球运动皮层神经元中谷氨酸脱氢酶活性的变化]
Zh Vyssh Nerv Deiat Im I P Pavlova. 1978 Mar-Apr;28(2):402-7.
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Zh Nevropatol Psikhiatr Im S S Korsakova. 1976 Dec;76(12):1806-10.
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[Biochemical characteristics of cerebral cortex neurocyte development following early exclusion of photic afferentation].[早期排除光传入后大脑皮质神经细胞发育的生化特征]
Zh Nevropatol Psikhiatr Im S S Korsakova. 1978;78(7):961-6.
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[Cytochemical indices of intercentral interrelations of the motor and visual analyzers during light deprivation].[光剥夺期间运动和视觉分析器中枢间相互关系的细胞化学指标]
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Zh Vyssh Nerv Deiat Im I P Pavlova. 1980 Jul-Aug;30(4):824-8.
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引用本文的文献

1
Effect of afferent visual impulses on morphological and biochemical indices of the development of neurons of the optical, motor, and parietal cortex of the brain.
Neurosci Behav Physiol. 1985 Nov-Dec;15(6):465-70. doi: 10.1007/BF01184254.