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[光剥夺期间大脑半球运动皮层神经元中谷氨酸脱氢酶活性的变化]

[Changes in glutamate dehydrogenase activity in the neurons of the motor cortexof the cerebral hemispheres during light deprivation].

作者信息

Busniuk M M

出版信息

Zh Vyssh Nerv Deiat Im I P Pavlova. 1978 Mar-Apr;28(2):402-7.

PMID:654581
Abstract

It has been shown that early light deprivation (keeping the rats for eight weeks from birth in a dark chamber) produces compensatory changes in the majority of pyramidal neurones in layers III and V of the brain motor area: significant enhancement of glutamatdehydrogenase activity activity in the bodies and processes of the neurones, increase of their volumes, augmentation of the number of neuroglial satellites with a high ferment activity. The revealed morphochemical changes, more pronounced in the layer V, are considered as a manifestation of enhanced functional activity of the coritcal end of the motor analyser, resulting from visual dereceptation.

摘要

研究表明,早期光剥夺(从出生起将大鼠置于黑暗室中八周)会使大脑运动区III层和V层的大多数锥体神经元产生代偿性变化:神经元胞体和突起中的谷氨酸脱氢酶活性显著增强,其体积增大,具有高发酵活性的神经胶质卫星数量增加。所揭示的形态化学变化在V层更为明显,被认为是由于视觉去传入导致运动分析器皮质端功能活动增强的表现。

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