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碱处理脂多糖对红细胞膜稳定性的影响。

Effect of alkali-treated lipopolysaccharide on erythrocyte membrane stability.

作者信息

Ciznár I, Shands J W

出版信息

Infect Immun. 1971 Oct;4(4):362-7. doi: 10.1128/iai.4.4.362-367.1971.

Abstract

The interaction of various lipopolysaccharides (LPS) with sheep erythrocytes was studied. When subjected to mild alkaline hydrolysis, the affinity of LPS for the red cell surface was greatly increased, as others have reported. In addition, excessive quantities of alkali-treated LPS (but not parent or heated products) were found to cause hemolysis of red cells. Experiments indicated that the hemolysis was caused by the LPS particles themselves and not by liberated free fatty acids.

摘要

研究了各种脂多糖(LPS)与绵羊红细胞的相互作用。如其他人所报道的那样,当进行轻度碱水解时,LPS对红细胞表面的亲和力大大增加。此外,发现过量的碱处理LPS(而非母体或加热产物)会导致红细胞溶血。实验表明,溶血是由LPS颗粒本身引起的,而非游离脂肪酸释放所致。

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