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多肽抗生素对蛋白质合成的抑制作用。I. 对完整细菌的抑制作用

Inhibition of protein synthesis by polypeptide antibiotics. I. Inhibition in intact bacteria.

作者信息

Ennis H L

出版信息

J Bacteriol. 1965 Oct;90(4):1102-8. doi: 10.1128/jb.90.4.1102-1108.1965.

DOI:10.1128/jb.90.4.1102-1108.1965
PMID:4954517
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC315780/
Abstract

Ennis, Herbert L. (St. Jude Children's Research Hospital, Memphis, Tenn.). Inhibition of protein synthesis by polypeptide antibiotics. I. Inhibition in intact bacteria. J. Bacteriol. 90:1102-1108. 1965.-The mechanism of inhibition of growth of cells by the polypeptide antibiotics of the PA 114, vernamycin, and streptogramin complexes was studied. This inhibition apparently was due to the selective inhibition of protein synthesis by these antibiotics. Ribonucleic acid synthesis was unaffected by concentrations of the antibiotics which completely inhibited protein synthesis. Deoxyribonucleic acid synthesis was slightly inhibited. These antibiotics are composed of a number of components. Mixtures of equal amounts of PA 114 A and PA 114 B or vernamycin A and Balpha were more active in stopping protein synthesis in intact cells than each of the components of the antibiotic complex alone. Mutants resistant to one of the antibiotics were resistant to all of the group and, in addition, were resistant to erythromycin and oleandomycin.

摘要

埃尼斯，赫伯特·L.（田纳西州孟菲斯市圣犹大儿童研究医院）。多肽抗生素对蛋白质合成的抑制作用。I.对完整细菌的抑制作用。《细菌学杂志》90:1102 - 1108。1965年。——研究了PA 114、弗纳霉素和链阳性菌素复合物等多肽抗生素对细胞生长的抑制机制。这种抑制显然是由于这些抗生素对蛋白质合成的选择性抑制。核糖核酸合成不受完全抑制蛋白质合成的抗生素浓度的影响。脱氧核糖核酸合成受到轻微抑制。这些抗生素由多种成分组成。等量的PA 114 A和PA 114 B或弗纳霉素A和Bα的混合物在阻止完整细胞中的蛋白质合成方面比抗生素复合物的每种单独成分更具活性。对其中一种抗生素耐药的突变体对该组所有抗生素都耐药，此外，还对红霉素和竹桃霉素耐药。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/24e2/315780/a15a52ae55dd/jbacter00427-0306-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/24e2/315780/a15a52ae55dd/jbacter00427-0306-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/24e2/315780/a15a52ae55dd/jbacter00427-0306-a.jpg

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Inhibition of protein synthesis by polypeptide antibiotics.. II. In vitro protein synthesis.多肽抗生素对蛋白质合成的抑制作用。II. 体外蛋白质合成
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