Kerr F, Brown M G, Irving J B, Hoskins M R, Ewing D J, Kirby B J
Lancet. 1975 Jun 28;1(7922):1397-400. doi: 10.1016/s0140-6736(75)92606-9.
The analgesic effect of self-administered nitrous oxide 50%/oxygen 50% ('Entonox" analgesic apparatus) was compared with air given by the same method in a double-blind trial in 81 patients with myocardial infarction. Self-administered nitrous oxide/oxygen, which was associated with a low frequency of side-effects, proved significantly more effective than air in the early relief of severe cardiac pain, but not in the relief of moderate or slight pain or when administration was continued after ten minutes.
在一项针对81名心肌梗死患者的双盲试验中，将自行使用的50%氧化亚氮/50%氧气（“恩托诺克斯”镇痛装置）的镇痛效果与通过相同方法给予的空气进行了比较。自行使用的氧化亚氮/氧气副作用发生率较低，在早期缓解严重心脏疼痛方面明显比空气更有效，但在缓解中度或轻度疼痛或十分钟后继续给药时则不然。
