Donen N, Tweed W A, White D, Guttormson B, Enns J
Can Anaesth Soc J. 1982 May;29(3):275-9. doi: 10.1007/BF03007131.
Pre-hospital self-administered analgesia using a 50:50 mixture of nitrous oxide and oxygen (Entonox) was evaluated in 240 patients. Of these, 93.4 per cent experienced either complete or partial relief from traumatic, chest, abdominal or back pain. Drowsiness was the most common side effect noted. No complications occurred during delivery of the mixture. Attention is drawn to the effect of extreme temperatures on the Entonox mixture and recommendations are made with respect to its use below-freezing climates. Because of its ease of use and short duration of action, Entonox appears to be well suited for the treatment of pre-hospital pain by Emergency Medical Technicians.
对240例患者使用一氧化二氮和氧气按50:50混合的气体（恩多诺克斯）进行院前自我给药镇痛评估。其中，93.4%的患者创伤性、胸部、腹部或背部疼痛得到完全或部分缓解。嗜睡是最常见的副作用。在混合气体给药过程中未发生并发症。文中提请注意极端温度对恩多诺克斯混合气体的影响，并就其在低于冰点气候下的使用提出了建议。由于其使用方便且作用持续时间短，恩多诺克斯似乎非常适合急救医疗技术人员用于院前疼痛治疗。
