McKinnon K D
Can Med Assoc J. 1981 Oct 15;125(8):836-40.
A pilot study of prehospital analgesia with 50% nitrous oxide and 50% oxygen was undertaken in patients experiencing severe pain from various sources. Under the supervision of an ambulance attendant N2O/O2 was administered through a face mask held by the patient and connected to a portable regulator/tank unit. Two types of units were evaluated -- Entonox (with premixed N2O and O2) and Nitronox (with separate cylinders of N2O and O2, the gases being mixed at the time of administration). Of the 72 patients 69 obtained worthwhile analgesia (marked or partial relief of pain) during treatment in the field or in the ambulance. There were no serious side effects, and those that did occur reflected N2O's expected action (e.g., giddiness). N2O/O2 is thus considered a safe and effective analgesic, suitable for use by ambulance personnel.
对因各种原因遭受剧痛的患者进行了一项院前使用50%氧化亚氮和50%氧气镇痛的试点研究。在救护车护理人员的监督下，通过患者手持并连接到便携式调节器/储气罐装置的面罩给予一氧化二氮/氧气。评估了两种装置——安桃乐（预混一氧化二氮和氧气）和耐乐品（一氧化二氮和氧气分别装在气瓶中，给药时气体混合）。72例患者中，69例在现场或救护车上治疗期间获得了有效的镇痛效果（疼痛明显减轻或部分缓解）。没有严重的副作用，出现的副作用反映了一氧化二氮的预期作用（如头晕）。因此，一氧化二氮/氧气被认为是一种安全有效的镇痛药，适合救护人员使用。
