O'Brien J R, Heywood J B
J Clin Pathol. 1966 Mar;19(2):148-53. doi: 10.1136/jcp.19.2.148.
The ;swirling' seen when platelet-rich plasma is stirred is caused by the average asymmetry of the platelets and a technique for recording the swirling is reported. After the addition of adenosine diphosphate, 5-hydroxytryptamine, thrombin, and collagen, platelets become rounded and more symmetrical immediately before they become sticky. Monoiodo-acetate and adenosine prevent both the change in shape and sticking whereas E.D.T.A. and p-tosyl arginine methylester prevent sticking but the shape still changes. Adrenaline produces sticking but no change in shape. The effects of temperature and E.D.T.A. are also reported. All these findings are discussed and diagrammatic representations of some reactions are tentatively proposed.
当搅拌富含血小板的血浆时出现的“漩涡”是由血小板的平均不对称性引起的，并且报道了一种记录漩涡的技术。加入二磷酸腺苷、5-羟色胺、凝血酶和胶原后，血小板在变得黏附之前会立即变圆且更加对称。碘乙酸盐和腺苷可防止形状改变和黏附，而乙二胺四乙酸（EDTA）和对甲苯磺酰精氨酸甲酯可防止黏附，但形状仍会改变。肾上腺素会导致黏附，但形状不变。还报道了温度和EDTA的影响。对所有这些发现进行了讨论，并初步提出了一些反应的示意图。
