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Specific binding sites for 5-hydroxytryptamine on rat blood platelets.5-羟色胺在大鼠血小板上的特异性结合位点。
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2
Proceedings: Inhibition of 5-hydroxy-(3H)-tryptamine binding to rat blood platelets by 5-HT antagonists and uptake inhibitors.论文集：5-羟色胺拮抗剂和摄取抑制剂对5-羟色胺（3H）与大鼠血小板结合的抑制作用
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3
The uptake of 6-methoxy-1,2,3,4-tetrahydro-beta-carboline and its effect on 5-hydroxytryptamine uptake and release in blood platelets.6-甲氧基-1,2,3,4-四氢-β-咔啉的摄取及其对血小板中5-羟色胺摄取和释放的影响。
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Saturable uptake of [3H]-tryptamine in rabbit platelets is inhibited by 5-hydroxytryptamine uptake blockers.兔血小板中[3H] - 色胺的饱和摄取受到5 - 羟色胺摄取阻滞剂的抑制。
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Similar kinetic characteristics of 5-hydroxytryptamine binding in blood platelets and brain membranes of rats.大鼠血小板和脑膜中5-羟色胺结合的相似动力学特征。
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Specific 5-hydroxytryptamine binding to rat platelets as a system to evaluate tricyclic antidepressants in plasma.以特异性5-羟色胺与大鼠血小板的结合作为评估血浆中三环类抗抑郁药的系统。
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Active transport of 5-hydroxytryptamine by plasma membrane vesicles isolated from human blood platelets.从人血小板中分离出的质膜囊泡对5-羟色胺的主动转运。
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9
Binding of 5-hydroxytryptamine to human blood platelets [proceedings].5-羟色胺与人类血小板的结合[会议论文集]
Br J Pharmacol. 1977 Nov;61(3):453P.
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Proceedings: Receptors for 5-hydroxytryptamine on rat blood platelets.论文集：大鼠血小板上5-羟色胺的受体
Thromb Diath Haemorrh. 1975 Nov 15;34(2):594.

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Naunyn Schmiedebergs Arch Pharmacol. 1980 Sep;313(3):189-94. doi: 10.1007/BF00505732.
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Uptake of 5-hydroxytryptamine by rat blood platelets and its inhibition by adenosine 5'-diphosphate.大鼠血小板对5-羟色胺的摄取及其被5'-二磷酸腺苷的抑制作用。
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Br J Pharmacol. 1977 Nov;61(3):453P.

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A NEW, POTENT AND SPECIFIC SEROTONIN INHIBITOR, (SQ 10,643) 2'-(3-DIMETHYLAMINOPROPYLTHIO) CINNAMANILIDE HYDROCHLORIDE: ANTISEROTONIN ACTIVITY ON UTERUS AND ON GASTROINTESTINAL, VASCULAR, AND RESPIRATORY SYSTEMS OF ANIMALS.一种新型、强效且特异性的血清素抑制剂，（SQ 10,643）2'-（3-二甲基氨基丙硫基）肉桂酰苯胺盐酸盐：对动物子宫及胃肠、血管和呼吸系统的抗血清素活性。
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PLATELET CLUMPING IN VITRO.体外血小板聚集
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[On the pharmacology of tofranil (N-(3-dimethylaminopropyl)-iminodibenzyl hydrochloride].关于多虑平（N-（3-二甲氨基丙基）-亚氨基二苄基盐酸盐）的药理学
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5-Hydroxytryptamine uptake and release in relation to aggregation of rabbit platelets.5-羟色胺摄取与释放与兔血小板聚集的关系
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The relation between the 5-hydroxytryptamine content and aggregation of rabbit platelets.兔血小板中5-羟色胺含量与聚集之间的关系。
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Effects of 5-hydroxytryptamine on platelet aggregation.5-羟色胺对血小板聚集的影响。
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Relative activities on and uptake by human blood platelets of 5-hydroxytryptamine and several analogues.5-羟色胺及几种类似物对人体血小板的相对活性及摄取情况
Br J Pharmacol. 1972 Jan;44(1):117-39. doi: 10.1111/j.1476-5381.1972.tb07244.x.
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Effect of aggregating agents and their inhibitors on the mean platelet shape.聚集剂及其抑制剂对平均血小板形状的影响。
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Letter: Rapid, sensitive microassay for platelet 5HT.信函：血小板5-羟色胺的快速、灵敏微量测定法。
Thromb Diath Haemorrh. 1974 May 15;31(2):366-7.
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A selective inhibitor of serotonin uptake: Lilly 110140, 3-(p-trifluoromethylphenoxy)-N-methyl-3-phenylpropylamine.一种血清素摄取的选择性抑制剂：礼来110140，3-（对-三氟甲基苯氧基）-N-甲基-3-苯丙胺。
Life Sci. 1974 Aug 1;15(3):471-9. doi: 10.1016/0024-3205(74)90345-2.

5-羟色胺在大鼠血小板上的特异性结合位点。

Specific binding sites for 5-hydroxytryptamine on rat blood platelets.

作者信息

Drummond A H, Gordon J L

出版信息

Biochem J. 1975 Jul;150(1):129-32. doi: 10.1042/bj1500129.

DOI:10.1042/bj1500129
PMID:1201004
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1165712/
Abstract

5-Hydroxytryptamine changes the shape of rat blood platelets by combination with a cinanserin-sensitive receptor which is not associated with the active uptake of 5-hydroxytryptamine. Binding of 5-hydroxy[3H]tryptamine to platelets at 4 degrees C demonstrates the presence of three saturable sites, and the highest-affinity site is apparently this 5-hydroxytryptamine receptor.

摘要

5-羟色胺通过与一种对辛那色林敏感的受体结合来改变大鼠血小板的形状，该受体与5-羟色胺的主动摄取无关。在4℃下，5-[³H]羟色胺与血小板的结合显示存在三个可饱和位点，而亲和力最高的位点显然就是这种5-羟色胺受体。