5-羟色胺在大鼠血小板上的特异性结合位点。
Specific binding sites for 5-hydroxytryptamine on rat blood platelets.
作者信息
Drummond A H, Gordon J L
出版信息
Biochem J. 1975 Jul;150(1):129-32. doi: 10.1042/bj1500129.
Abstract
5-Hydroxytryptamine changes the shape of rat blood platelets by combination with a cinanserin-sensitive receptor which is not associated with the active uptake of 5-hydroxytryptamine. Binding of 5-hydroxy[3H]tryptamine to platelets at 4 degrees C demonstrates the presence of three saturable sites, and the highest-affinity site is apparently this 5-hydroxytryptamine receptor.
摘要
5-羟色胺通过与一种对辛那色林敏感的受体结合来改变大鼠血小板的形状，该受体与5-羟色胺的主动摄取无关。在4℃下，5-[³H]羟色胺与血小板的结合显示存在三个可饱和位点，而亲和力最高的位点显然就是这种5-羟色胺受体。
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