Spector S L, Staudenmayer H, Kinsman R A, Fukuhara J, Westmoreland C
Allergy. 1979 Jun;34(3):167-73. doi: 10.1111/j.1398-9995.1979.tb01564.x.
Levels of airways hyperreactivity, as indexed by methacholine and histamine thresholds, were determined for hospitalized asthmatic patients using the serial concentration, constant-breath method. Airways hyperreactivity was categorized into low and high based on a split of the sample of subjects tested. These categories were unrelated to pulmonary function measurements obtained throughout hospitalization. Patients having high airways hyperreactivity to histamine or methacholine were admitted for intensive inpatient care at a young age, had an earlier age of onset, and had asthma of longer duration than patients having low airways hyperreactivity. These latter results suggested that relatively greater airways hyperreacticity is more likely to be associated with early onset of the illness.
采用系列浓度、恒定呼吸法，对住院哮喘患者测定以乙酰甲胆碱和组胺阈值为指标的气道高反应性水平。根据受试对象样本的划分，将气道高反应性分为低和高两类。这些类别与住院期间获得的肺功能测量值无关。与气道高反应性低的患者相比，对组胺或乙酰甲胆碱气道高反应性高的患者在年轻时就因强化住院治疗而入院，发病年龄更早，哮喘病程更长。后一组结果表明，相对较高的气道高反应性更有可能与疾病的早发有关。
