Mather L E, Tucker G T, Murphy T M, Stanton-Hicks M D, Bonica J J
Anaesth Intensive Care. 1979 Aug;7(3):215-21. doi: 10.1177/0310057X7900700302.
Intravenous infusions of etiodocaine 50, 75 and 100 mg and bupivacaine 75 mg were carried out over ten minutes in healthy young adult males. Cardiovascular sequelae were generally trivial at all doses. A collection of subjective central nervous system symptoms were described which may be regarded as early warning of impending local anaesthetic toxicity. Plasma concentrations of etidocaine were proportional to dose and ranged from 2 micrograms/ml to 5 micrograms/ml at the termination of the infusion. Plasma concentrations of bupivacaine were similar to those from the same dose of etidocaine but declined more slowly on cessation of infusion.
在健康年轻成年男性中，在10分钟内静脉输注50毫克、75毫克和100毫克的依替卡因以及75毫克的布比卡因。所有剂量下的心血管后遗症通常都很轻微。描述了一系列主观中枢神经系统症状，这些症状可被视为即将发生局部麻醉药毒性的早期预警。依替卡因的血浆浓度与剂量成正比，输注结束时范围为2微克/毫升至5微克/毫升。布比卡因的血浆浓度与相同剂量依替卡因的血浆浓度相似，但在输注停止后下降得更慢。
