Wiklund L, Jorfeldt L
Acta Anaesthesiol Scand. 1981 Jun;25(3):200-8. doi: 10.1111/j.1399-6576.1981.tb01637.x.
The splanchnic turn-over of energy metabolites in circulating blood has been studied in four groups of young, healthy volunteers, receiving intravenous infusions of physiological saline (n = 5), lidocaine 4 mg/min (n = 7), bupivacaine 2 mg/min (n = 7) and etidocaine 2 mg/min (n = 8). The results showed that the local anaesthetic agents increased the splanchnic blood flow and oxygen consumption, the uptake of glycerol and lactate, and the release of 3-hydroxybutyrate. These effects are adrenaline-like but cannot be explained by one single mechanism involving increased activity of the sympathetic nervous system. Only a minor part of the increased oxygen uptake could be attributed to the energy cost of drug metabolism.
在四组年轻健康志愿者中研究了循环血液中能量代谢产物的内脏周转率，这些志愿者分别接受静脉输注生理盐水（n = 5）、利多卡因4毫克/分钟（n = 7）、布比卡因2毫克/分钟（n = 7）和依替卡因2毫克/分钟（n = 8）。结果显示，局部麻醉药增加了内脏血流量和氧耗量、甘油和乳酸的摄取以及3-羟基丁酸的释放。这些作用类似肾上腺素，但不能用涉及交感神经系统活性增加的单一机制来解释。增加的氧摄取中只有一小部分可归因于药物代谢的能量消耗。
